2023年3月4日 · 在对其具体通路的研究中发现 ： ifn可同时介导经典和非经典mhc i类抑制检查点来促进icb耐药的免疫逃逸。 IFN介导免疫抑制的两种机制 在体内和体外筛选中，一些IFN敏感和影响抗原呈递的基因在体外产生T细胞杀伤耐药性，但在体内则会引起免疫原性反应。

Mechanisms of IFN-gamma to enhance MHC class I antigen processing and presentation were summarized in this literature review. IFN-gamma up-regulates MHC class I expression and antigen processing and presentation on cells, since IFN-gamma can induce multiple gene expressions that are related to MHC class I antigen processing and presentation.

肿瘤特异性T细胞通过识别 主要组织相容性复合体 (MHC)-抗原复合物与靶细胞结合后，能释放颗粒酶和穿孔素，从而诱导靶细胞凋亡。 在这种情况下，肿瘤固有的IFN信号传导与采用肿瘤特异性T细胞的ACT疗法特别相关。 为了研究肿瘤固有IFN信号对肿瘤特异性T细胞抗肿瘤效果的直接影响，团队在B16小鼠黑色素瘤细胞中建立了IFN信号缺陷的模型 (Jak1或Jak2缺失)，进行体外过继转移研究。 Jak1或Jak2缺失的肿瘤对ICB无反应，而ACT对敲除Jak2的肿瘤有效，但对敲 …

2023年3月5日 · 在对其具体通路的研究中发现：ifn可同时介导经典和非经典mhc i类抑制检查点来促进icb耐药的免疫逃逸。 IFN介导免疫抑制的两种机制 在体内和体外筛选中，一些IFN敏感和影响抗原呈递的基因在体外产生T细胞杀伤耐药性，但在体内则会引起免疫原性反应。

2025年2月28日 · Accumulated evidence suggested that restoring MHC I expression is an effective strategy for enhancing tumor immunotherapy. This review focuses on mechanisms underlying MHC I downregulation include gene deletion and mutation, transcriptional inhibition, reduced mRNA stability, increased protein degradation, and disruption of endocytic trafficking.

2022年6月8日 · Recently, we demonstrated that IFN-γ signaling induces the up-regulation of major histocompatibility complex (MHC) class II molecules by tumor LECs, which locally promote the suppressive functions of regulatory T cells, leading to an inhibition of cytotoxic CD8 + T lymphocyte (CTL) effector functions and promoting tumor growth .

IFNγ changed the SS and MRCL TME, inducing tumor-surface MHC-I expression and significant T-cell infiltration (p<0.05). Gene expression analysis suggested increased tumor antigen presentation and less exhausted phenotypes of the tumor-infiltrating T cells.

2023年12月2日 · IFN-α and IFN-β signaling dysregulation impacts the normal transcription of MHC-I molecules. IFN-γ is a frequent signaling pathway to regulate the MHC-I gene transcription. Other signaling pathways, including TGF-β, EGFR and HER2, can also act as regulators in the MHC-I mediated the antigenic presentation.

IFN-α mediates a long-lasting and preferential MHC class I overexpression in human beta cells, which is not affected by the subsequent addition of JAK inhibitors. These observations suggest that IFN-α-stimulated long-lasting MHC class I expression may amplify beta cell antigen presentation during th …

Interferons (IFNs) were first discovered as an important anti-viral factor that interferes with viral replication in mammalian cells. Three classes of IFNs (Type I, II, and III) have been identified and categorized on the basis of their structural homology and …

IFNγ changed the SS and MRCL TME, inducing tumor-surface MHC-I expression and significant T-cell infiltration (P < 0.05). Gene-expression analysis suggested increased tumor antigen presentation and less exhausted phenotypes of the tumor-infiltrating T cells.

The cytokine interferon‐γ (IFNγ) can induce expression of MHC class II (MHCII) on many different cell types, leading to antigen presentation to CD4+ T cells and immune activation. This has also been linked to anti‐tumour immunity and ...

2009年8月13日 · IFN-γ up-regulates MHC class I antigen presentation via activation of JAK/STAT1 signal transduction pathway. Mechanisms of IFN-γ to enhance MHC class I antigen processing and presentation were summarized in this literature review.

2021年11月30日 · Many patients diagnosed with various types of cancer have inhibited the IFNγ signaling pathway. This review explores how anomalies associated with IFNγ signaling in tumor cells affect HLA-I expression, current immunotherapies association, and outcome. Globally, MHC-I lesions could be divided into reversible and permanent.

2022年2月8日 · We identified a novel IFN-I-induced activation state of CD11b + cDCs, which we called ISG + DCs, that was capable of driving anti-tumor CD8 + T cell immunity by MHC class I dressing with tumor-derived pMHC class I complexes.

6 天之前 · Monocytes, particularly macrophages, serve as the major source of type 1 IFN production through this pathway in human body . Thus, investigating the roles of cGAS-STING signaling in TAMs and its effects on the TME are of great importance. ... coupled with reduced levels of MHC-I complexes on plasma membranes. This reduction might be ...

We here summarize the current knowledge about (i) pleiotropic functions of IFNs that mediate various biological responses, (ii) mechanisms of action and transduction pathways, (iii) the effect of type I and type II IFNs on the expression levels of molecules involved in proper major histocompatibility complex (MHC) class I and class II antigen ...

2025年3月11日 · Specifically, the MHC-II molecule presents the peptide to a CD4+ T-cell, also known as a T-helper cell. The peptide residues exposed to the T-cell receptor and primarily involved in binding are positions 2, 3, 5, 7, and 8 . Upon activation, T-helper cells can differentiate into distinct subsets, including T-helper 1 (T H 1) cells. These cells ...

2019年8月1日 · IFNγ can enhance expression of surface major histocompatibility complex (MHC) molecules and increase the processing and presentation of tumor-specific antigens (7), thus facilitating T-cell recognition and cytotoxicity (8–11).

The cytokine interferon-γ (IFNγ) can induce expression of MHC class II (MHCII) on many different cell types, leading to antigen presentation to CD4 + T cells and immune activation. This has also been linked to anti-tumour immunity and graft-versus-host disease.