Regulation of the HBV Entry Receptor NTCP and its Potential in ...
Sodium taurocholate co-transporting polypeptide (NTCP), a transmembrane protein highly expressed in human hepatocytes and a mediator of bile acid transport, has been identified as …
Targeting NTCP for liver disease treatment: A promising strategy
2024年9月1日 · This paper thoroughly investigates the function of NTCP for regulating bile acid regulation, its correlation with hepatitis B and D infections, and its association with various liver …
Epigenetic reprogramming promotes the antiviral action of
2021年6月2日 · Herein, we showed that an epigenetic regimen with non-cytotoxic doses of the demethylating compound 5-azacytidine restored the anti-HBV action of IFNα in epigenetically …
IFN-α inhibits HBV transcription and replication by promoting …
2021年9月8日 · In this study, we report that IFN-α2b enhances the histone deacetylase 3 (HDAC3)-mediated de-2-hydroxyisobutyrylation of histone H4 lysine 8 (H4K8) on HBV …
SAMD4 family members suppress human hepatitis B virus by …
2020年4月27日 · IFN-α is widely used to treat hepatitis B, but its anti-HBV mechanism is not fully understood. In this study, we screened and identified SAMD4A as the strongest antiviral ISG …
Hepatitis B virus sensitivity to interferon-α in hepatocytes is more ...
In the cell-culture-based HBV infection models, the sensitivity of HBV to IFN-α in hepatocytes is determined more by the cell-intrinsic IFN response than by viral genotype, and improvement of …
Hepatitis D virus-induced interferon response and administered ...
Results: Cell division-mediated HDV spread was highly efficient following infection of HuH7 NTCP cells (defective in IFN production), but profoundly restricted in infected IFN-competent …
Infection courses, virological features and IFN-α responses of HBV ...
These data indicate that HepG2-NTCP cells are less susceptible to infection by HBVcc than the PXB cells. HBVcc genotypes respond differently to antiviral effect of hIFN-α2a in PXB cells
Hepatitis D virus-induced interferon response and administered ...
2022年10月1日 · Cell division-mediated HDV spread was highly efficient following infection of HuH7NTCP cells (defective in IFN production), but profoundly restricted in infected IFN …
TRIM56 impairs HBV infection and replication by inhibiting HBV …
2022年11月1日 · In this study, we identified and characterized TRIM56 as a potent IFN-inducible effector that strongly suppressed HBV replication in HepG2-NTCP and primary human …
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