Insulin-Like Growth Factors Are Key Regulators of T Helper 17 ...
2020年4月14日 · Disruption of Th17-Treg cell balance is implicated in a number of immune-mediated diseases, many of which display dysregulation of the insulin-like growth factor (IGF) system. Here, we show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 ...
2020年4月14日 · Disruption of Th17-Treg cell balance is implicated in a number of immune-mediated diseases, many of which display dysregulation of the insulin-like growth factor (IGF) system. Here, we show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Insulin and IGF-1 have both overlapping and distinct effects on CD4
2024年2月21日 · Given our findings that IGF-1R is significantly upregulated on Th17 cells compared to other CD4 + T helper subsets (Fig. 1e–f), and treatment with IGF-1 causes an increase in IL-17 production...
Disruption of Th17-Treg cell bal-ance is implicated in a number of immune-mediated diseases, many of which display dysregulation of the insulin-like growth factor (IGF) system. Here, we show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple compo-nents of the IGF system.
The critical roles of IGFs in immune modulation and inflammation
2024年11月1日 · IGFs regulate T cell development, function, and balance between Th17 and Tregs. IGFs provide new therapeutic targets for treating inflammatory diseases and cancer. Insulin-like growth factors (IGFs) are crucial for embryonic and postnatal growth and development, influencing cell survival, metabolism, myogenesis, and cancer progression.
胰岛素样生长因子是自身免疫中 T Helper 17 调节性 T 细胞平衡的 …
通过 IGF 受体 (IGF1R) 的信号传导激活了蛋白激酶 B-哺乳动物雷帕霉素靶点 (AKT-mTOR) 通路，增加了有氧糖酵解，有利于 Th17 细胞分化而不是 Treg 细胞，并促进了促炎基因表达特征的增强。
胰岛素样生长因子调控Th17与Treg细胞的平衡 - 科学网
2020年4月14日 · 美国阿拉巴马大学伯明翰分校Casey T. Weaver研究团队的一项最新研究显示，自身免疫反应中胰岛素样生长因子（IGF）是辅助性T细胞17（Th17）调节T细胞 ...
The ultimate microbial composition for correcting Th17/Treg cell ...
2025年1月10日 · Exogenous Th17 cells upregulate TGF-β to promote the upregulation of the surface marker molecule Foxp 3 in Treg cells and inhibit the expression of IL-23R in Th17 cells, thereby causing damage to Th17 cells.
董晨院士团队Immunity：细胞因子启动Th17细胞分化的新机制_澎 …
2020年8月21日，清华大学免疫学研究所董晨院士团队在Cell Press细胞出版社期刊Immunity上发表题为“The conserved non-coding sequences CNS6 and CNS9 control cytokine-induced Rorc transcription during T helper 17 cell differentiation”的文章，发现起始Th17细胞分化所必需的两个细胞因子IL-6和TGF-β ...
Growth hormone releasing hormone signaling promotes Th17 cell …
2023年6月6日 · In multiple organs, GH induces the production of insulin-like growth factor 1 (IGF-1), which was recently reported to be a key regulator for Th17-regulatory T (Treg) cell balance in...