Insulin-like growth factor 1 receptor - Wikipedia
The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 ( IGF-1 ) and by a related hormone called IGF-2 .
Insulin-like growth factor 1 - Wikipedia
IGF-1 binds to at least two cell surface receptor tyrosine kinases: the IGF-1 receptor (IGF1R), and the insulin receptor. Its primary action is mediated by binding to its specific receptor, IGF1R, which is present on the surface of many cell types in many tissues [further explanation needed]. Binding to the IGF1R initiates intracellular signaling.
Insulin-Like Growth Factor 1 Receptor - ScienceDirect
Insulin-like growth factor-1 receptor (IGF-1R, located in 15q26.3) is a cell surface receptor with tyrosine kinase activity that activates the PI3K/Akt/mTOR and RAS/RAF/MAPK signaling pathways by binding IGF-1 or IGF-2 ligand [30].
胰岛素样生长因子1 - 维基百科，自由的百科全书
igf-1是一个在三级结构上与胰岛素类似的激素，在儿童成长发育中有重要作用，并持续在成人的合成代谢中起作用。 一种人工合成的IGF-1类似物， 美卡舍明 （ 英语 ： mecasermin ） ，用于治疗发育停滞 [ 9 ] 。
IGF-1R (胰岛素样生长因子受体) - MCE-生物活性分子大师
IGF-1R (Insulin-like growth factor 1 receptor), a receptor tyrosine kinase, is activated upon binding to the ligands IGF-1 or IGF-2 leading to cell growth, survival and migration of both normal and cancerous cells.
Expression, Regulation, and Function of IGF-1, IGF-1R, and IGF-1 ...
2003年11月6日 · The vascular insulin-like growth factor (IGF)-1 system includes the IGFs, the IGF-1 receptor (IGF-1R), and multiple binding proteins. This growth factor system exerts multiple physiologic effects o...
Structural basis of the activation of type 1 insulin-like ... - Nature
2019年10月8日 · Type 1 insulin-like growth factor receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation, and can be activated...
IGF1R Gene - GeneCards | IGF1R Protein | IGF1R Antibody
2024年12月25日 · IGF1R (Insulin Like Growth Factor 1 Receptor) is a Protein Coding gene. Diseases associated with IGF1R include Insulin-Like Growth Factor I and Growth Delay Due To Insulin-Like Growth Factor I Resistance. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.
Nat Commun：揭示胰岛素样生长因子受体IGF1R激活的分子机制
2019年10月13日 · 一型胰岛素样生长因子受体（Type 1 insulin-like growth factor receptor， IGF1R）属于受体酪氨酸激酶家族（receptor tyrosine kinases， RTKs），胰岛素受体亚家族，位于细胞膜上，可以被胰岛素样生长因子（IGF1或IGF2）激活，引起自身酪氨酸激酶结构域的磷酸化并起始胞内信号 ...
什么是胰岛素样生长因子1受体(IGF-1R)？ - 知乎
胰岛素样生长因子1受体 (IGF-1R)位于人类细胞表面，是受激素胰岛素样生长因子1 (IGF-1)和另一相关激素胰岛素样生长因子2 (IGF-2)激活的跨膜受体，属于酪氨酸激酶受体的一大类。 IGF-1R介导IGF-1的功能，后者是一个在分子结构上类似于胰岛素的多肽激素，在生长发育和成人的合成代谢中有重要作用，可引起骨骼肌或其它靶组织的过度增殖。 缺失IGF-1R的小鼠在发育后期会死亡，表现为体重急剧下降，证明该受体对生长具有强烈的促进作用。 研究表明IGF-1R与一 …