The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of …

胰岛素样生长因子1受体 （英語： insulin-like growth factor 1 receptor，IGF-1R）是人类 细胞 表面发现的 蛋白质，是激素 胰岛素样生长因子1 （IGF-1）的 细胞表面受体，属于 酪氨酸激酶 受体家族。

Signalling through the IGF-1R is the principal pathway responsible for somatic growth in fetal mammals, while somatic growth in postnatal animals is achieved through the synergistic interaction of growth hormone (GH) and the IGFs.

胰岛素样生长因子1受体 (IGF-1R)位于人类细胞表面，是受激素胰岛素样生长因子1 (IGF-1)和另一相关激素胰岛素样生长因子2 (IGF-2)激活的跨膜受体，属于酪氨酸激酶受体的一大类。

2024年12月25日 · IGF1R (Insulin Like Growth Factor 1 Receptor) is a Protein Coding gene. Diseases associated with IGF1R include Insulin-Like Growth Factor Iand Growth Delay Due To Insulin-Like Growth Factor I Resistance.

2019年10月8日 · Type 1 insulin-like growth factor receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation, and can be activated by...

2003年11月6日 · The vascular insulin-like growth factor (IGF)-1 system includes the IGFs, the IGF-1 receptor (IGF-1R), and multiple binding proteins. This growth factor system exerts multiple physiologic effects on the vasculature through both endocrine and …

IGF-1R 可以启动 PI3K/AKT/mTOR 信号和 Ras/Raf/MEK/MAPK 通路的激活，从而激活多种转录因子（如 ELK-1、CREB 和 AP-1）来调节细胞增殖、存活、分化、运动、侵袭和血管生成。

2019年10月13日 · 一型胰岛素样生长因子受体（Type 1 insulin-like growth factor receptor， IGF1R）属于受体酪氨酸激酶家族（receptor tyrosine kinases， RTKs），胰岛素受体亚家族，位于细胞膜上，可以被胰岛素样生长因子（IGF1或IGF2）激活，引起自身酪氨酸激酶结构域的磷酸化并起始胞内信号传导，调控细胞的生长和分化，以及高等生物的生长、发育、衰老等各种生命活动。 大多数RTK在被配体激活之前以单体形式存在，配体诱使RTK二聚化，从而使酪氨酸结构 …

IGF I receptor is involved in apoptosis protection in human preadipocytes and adipocytes. To further understand the role of the type I insulin-like growth factor (IGF) receptor (IGF1R) in cancer metastasis we inhibited signaling via IGF1R using a C-terminal-truncated IGF1R.