IGFBP-5 是 IGFBPs 家族中最保守的蛋白，且作为一个主要的调控因子调控细胞的生长和发育等过程。 以 IGF-IGFBP-ALS (acid labie subunit)三聚体形式存在于血液中，这种三聚体的作用是运输和延长 IGFs 的半衰期、调节血液中 IGFs 的浓度。 小鼠IGFBP-5 cDNA编码271个氨基酸 (aa)残基前体蛋白和19个aa残基信号肽，这些信号肽被加工成252个aa残基成熟蛋白。 到目前为止，IGFBP-5在所有研究过的脊椎动物中都有发现，它的同源氨基酸序列通常是所有IGFBP类型中氨基酸 …

Insulin-like growth factor-binding protein 5 (IBF-5) is a protein that in humans is encoded by the IGFBP5 gene. [5] An IGFBP5 gene was recently identified as being important for adaptation to varying water salinity in fish.

2024年12月25日 · IGFBP5 (Insulin Like Growth Factor Binding Protein 5) is a Protein Coding gene. Diseases associated with IGFBP5 include Insulin-Like Growth Factor I and Pulmonary Fibrosis.

2020年3月3日 · In this review, we survey and discuss what is currently known about IGFBP-5 in normal physiology and human disease. Based on recent in vivo genetic evidence, we suggest that IGFBP-5 is a multifunctional protein with the ability to act as a molecular switch to conditionally regulate IGF signaling.

2020年3月2日 · Among the six distinct types of IGFBPs, IGFBP-5 is the most highly conserved across species and has the broadest range of biological activities. IGFBP-5 is expressed in diverse cell types, and its expression level is regulated by a variety of signaling pathways in different contexts.

IGFBP-5 expression prevented tumor growth and inhibited tumor vascularity in a xenograft model of human ovarian cancer. These results are the first evidence showing that IGFBP-5 plays a role as tumor suppressor by inhibiting angiogenesis; IGFBP-5 promotes muscle cell differentiation by binding to and switching on the IGF-II auto-regulation loop.

胰岛素样生长因子结合蛋白 5 （insulin-like growth factor-binding protein 5， IGFBP5）是一种重要的分泌蛋白，属于IGFBP家族（IGFBP1～IGFBP7），其与多种组织中的炎症和纤维化有关 [6-9]。 研究发现IGFBP5在DKD中的表达显著上调。 然而，IGFBP5在DKD中的功能及其机制尚不清楚。 2022年4月13日，解放军总医院的 洪权 教授课题组在 Cell Death & Disease 上发表了题为 “IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3 -mediated …

2025年2月8日 · IGFBP5 modulates lipid metabolism and insulin sensitivity through activating AMPK pathway in non-alcoholic fatty liver disease. Downregulation of PAPP-A2 expression or upregulation of IGFBP-5 expression can reduce collagen synthesis and cartilage proliferation.

igfbp-5 蛋白是 igfbp 家族的成员，可显着延长 igf 的半衰期并调节其在细胞培养中的生长促进作用。 多功能 IGFBP-5 可以通过改变与 IGF 受体相互作用的动力学来抑制或刺激细胞对 IGF 的反应。

Enables insulin-like growth factor I binding activity. Involved in several processes, including cellular response to cAMP; regulation of smooth muscle cell migration; and regulation of smooth muscle cell proliferation. Part of insulin-like growth factor ternary complex.