2022年4月14日 · Insulin-like growth factors binding protein-6 (IGFBP-6) is involved in a relevant number of cellular activities and represents an important factor in the immune response, particularly in human dendritic cells (DCs). Over the past several years, significant insights into the IGF-independent effects o …

在系统性红斑狼疮中，IGFBP2、IGFBP4和IGFBP6被基于阵列的蛋白质组学筛选发现为狼疮的诊断生物标志物。 IGFBP-3的减少和IGF-I的升高同时发生，可能会使肿瘤生长增加。 这两个潜在的生物标志物和癌症之间的机制尚未证实，但已有多项研究用于肺癌的筛查。 肺癌早期检测率较低，LDCT筛查有较高的假阳性。 为了更明确的界定肺癌，迫切需要开发相关的生物标志物，IGFBPs已成为这类研究的前沿热点。 IGFBP家族成员已被证明参与肿瘤的发展和进程，并 …

Results suggest that insulin like growth factor binding protein 6 (IGFBP6) may be an independent prognostic biomarker for nasopharyngeal carcinoma (NPC). We identified a novel SNP variant, Chr12:g.53494591T>C. c.T430C (p.S144P) in the insulin-like …

Insulin-like growth factors binding protein-6 (IGFBP-6) is involved in a relevant number of cellular activities and represents an important factor in the immune response, particularly in human dendritic cells (DCs).

2024年12月25日 · IGFBP6 (Insulin Like Growth Factor Binding Protein 6) is a Protein Coding gene. Diseases associated with IGFBP6 include Insulin-Like Growth Factor I and Acth-Secreting Pituitary Adenoma.

胰岛素样生长因子结合蛋白 6： 实现相同的蛋白质结合活性和胰岛素样生长因子 ii 结合活性。参与细胞迁移和应激激活的 mapk 级联的正调节。胰岛素样生长因子二元复合物的一部分。与肥胖有关。

IGFBP-6 has recently been shown to have a number of IGF-independent actions, including promotion of apoptosis in some cells and inhibition of angiogenesis. IGFBP-6 also induces migration of tumour cells including rhabdomyosarcomas by an IGF-independent mechanism. This chemotactic effect is mediated by MAP kinases.

2022年4月14日 · This review aims at describing the current understanding of mechanisms that link IGFBP-6 and fibrosis development and at highlighting the multiple roles of IGFBP-6 to provide an insight into evolutionarily conserved mechanisms that can be relevant for inflammation, tumor immunity, and immunological diseases.

2010年7月1日 · Insulin-like growth factor binding protein-6 (IGFBP-6) is a growth inhibitory protein that regulates the availability of insulin-like growth factors (IGFs). We recently reported that IGFBP-6 exerts intracellular actions via its translocation to the nucleus.

胰岛素样生长因子结合蛋白-6（insulin-like growth factor binding protein-6，IGFBP-6）是胰岛素样生长因子-2（insulin-like growth factor-2，IGF-2）的主要调节因子，近年研究 新发现，IGFBP-6具有独立于IGF-2的功能，包括抑制血管新生、促进细胞迁移。