The interleukin-1 (IL-1) family of cytokines and receptors is unique in immunology because the IL-1 family and Toll-like receptor (TLR) families share similar functions. More than any other cytokine family, the IL-1 family is primarily associated ...

2010年1月18日 · This Review provides a comprehensive and contemporary overview of the interleukin-1 (IL-1) family: their expression and regulation, their effects on innate immune cells, their regulation of...

This pathway summarizes extracellular and intracellular signaling of IL-1α or IL-1β, including positive- and negative-feedback mechanisms that amplify or terminate the IL-1 response.

We discuss the varied roles of IL-1 family members in immune homeostasis and their contribution to pathologies, including autoimmunity and auto-inflammation, dysmetabolism, cardiovascular disorders, and cancer. The trans-disease therapeutic activity of anti-IL-1 strategies argues for immunity and inflammation as a metanarrative of modern medicine.

2019年6月6日 · Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease.

For the next 40 years, the intravenous bolus injection of supernatants from leukocytes into rabbits with indwelling rectal thermometers was the most rapid and most reliable bioassay for what would later come to be called IL-1. Many scientists subjected the supernatants to increasing levels of purification but this turned out to be a daunting task.

IL-1 production (secreted and cell-associated) was measured in monocyte cultures stimulated by a variety of agents in vitro. Monocytes either adherent to conventional plastic culture plates in serum-free conditions, or in suspension in culture ...

2024年5月29日 · The precise regulation of IL-1R signaling is indispensable for orchestrating appropriate immune responses, as unchecked IL-1 signaling has been implicated in inflammatory disorders, including Th17-mediated autoimmunity. This review provides a thorough exploration of the IL-1R signaling complex and its pivotal roles in immune regulation.

2000年5月1日 · The interleukin 1 toll-like receptor superfamily is an expanding family of receptors, functioning as a rapid defense response to infection and injury, and possibly having other roles in human disease.

IL-1 是重要的炎性介质之一， 也是一种热原质成分， 具有致热和介导炎症的作用。 它主要在细胞免疫激活中发挥调节作用。 IL-1 受各种刺激因子（包括抗原、 内毒素、 细菌及病毒等）所诱导， 在急性和慢性炎症的致病过程发挥重要作用， 并与糖尿病、 类风湿关节炎和牙周炎的病理过程密切相关。 IL-1 参与机体造血系统、 神经、 内分泌系统的反应， 以及某些抗肿瘤的病理生理过程， 它还介导急性髓性白血病、 急性淋巴细胞白血病及多发性骨髓瘤的发病机制中。 IL-1 测定依 …