IL-22BP与IL-22的亲和力高20 - 1000倍，是IL-22生物活性的内源性抑制剂。 IL-22与其受体结合后，通过 JAK-STAT通路，主要激活STAT3，也可激活STAT1和STAT5, IL-22还可触发NF-kB，MAPK和PI3K-Akt-mTOR信号通路。 IL-22介导的信号通路能够增强抗炎、有丝分裂、增殖和抗凋亡基因的表达，促进局部组织再生和宿主防御的细胞效应。 T细胞和固有淋巴样细胞是IL-22的主要细胞来源。 其特异性受体IL-22R1的表达局限于非造血细胞，这使得IL-22/IL-22R1途径成 …

In this review, we will focus on IL-22BP, including its regulation, role in IL-22 biology and inflammation, and promise as a therapeutic. IL-22 can be protective or pathogenic, depending on the context of inflammation. IL-22BP also has divergent roles.

IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1).

2021年11月16日 · In this review, we will focus on IL-22BP, including its regulation, role in IL-22 biology and inflammation, and promise as a therapeutic. IL-22 can be protective or pathogenic, depending on the context of inflammation. IL-22BP also has divergent roles.

Interleukin-22 receptor subunit alpha-2 (IL-22RA2), also known as interleukin-22 binding protein (IL-22BP) is a naturally secreted monomeric protein acting as an interleukin-22 (IL-22) antagonist with inhibitory effects on IL-22 activity in vivo.

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T-helper (Th)-17 cells, γδ T cells, NKT cells and newly described innate lymphoid cells (ILCs). Knowledge of IL-22 biology has rapidly evolved since its ...

il-22除了其功能受体外，还有一种内源性拮抗剂 il-22结合蛋白 (il-22bp，又称il-22ra2)。il-22bp与il-22的亲和力高20 - 1000倍，是il-22生物活性的内源性抑制剂。 IL-22BP与IL-22的亲和力高20 - 1000倍，是IL-22生物活性的内源性抑制剂。

2024年12月1日 · IL-22 is a cytokine in the IL-10 cytokine family that has garnered increased attention in recent years due to its intimate link in promoting resolution of inflammatory insults, while simultaneously being over expressed in certain fibrotic and …

il-22 蛋白是一种分泌型 il-10 家族细胞因子，参与炎症反应、活性氧代谢过程以及上皮细胞的再生和扩散。 IL-22 通过 STAT3、ERK1/2、MAPK 和 PI3K / AKT 通路促进细胞存活和增殖。

2014年8月6日 · Interleukin (IL)-22 exerts essential roles in eliciting antimicrobial immunity and maintaining mucosal barrier integrity within the intestine 6, 7. Here we investigate the...