The interleukin-1 (IL-1) family of cytokines and receptors is unique in immunology because the IL-1 family and Toll-like receptor (TLR) families share similar functions. More than any other cytokine family, the IL-1 family is primarily associated ...

2019年6月6日 · IL-1 blockade therapy using anakinra is successful in patients with psoriatic arthritis, ankylosing spondylitis, and RA.

2010年1月18日 · This Review provides a comprehensive and contemporary overview of the interleukin-1 (IL-1) family: their expression and regulation, their effects on innate immune cells, their regulation...

IL-1 activates cells of the innate and adaptive immune system and exerts a wide range of biological activities that are protective during infection, such as promoting fever, vasodilation, hematopoiesis, angiogenesis, the acute phase response, leukocyte attraction and extravasation, lymphocyte activation, and antibody synthesis (Garlanda et al ...

2010年1月19日 · This pathway summarizes extracellular and intracellular signaling of IL-1alpha or IL-1beta, including positive- and negative-feedback mechanisms that amplify or terminate the IL-1 response.

2010年1月19日 · IL-1–type cytokines are major mediators of innate immune reactions, and blockade of the founding members IL-1α or IL-1β by the interleukin-1 receptor antagonist (IL-1RA) has demonstrated a central role of IL-1 in a number of human autoinflammatory diseases.

2022年4月5日 · In mammals, IL-1 is a superfamily of eleven structurally similar proteins, all involved in inflammation or its control, which mainly act through binding to specific receptors on the plasma membrane of target cells. IL-1 receptors are also a family of ten structurally similar transmembrane proteins that assemble in heterocomplexes.

The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of inflammation and fibrosis in multiple tissues including the lung. IL-1 ...

2010年2月23日 · This Review examines the biological functions of IL-1 and the use of IL-1-targeting agents in the treatment of various human diseases.

2024年10月5日 · IL-1 is a pleiotropic cytokine involved in a wide range of immune and non-immune processes in both normal and pathological conditions. IL-1 activates intracellular MyD88 and signals by binding to its specific receptors.