2020年5月20日 · We review our findings that (1) TSHR couples to several different G proteins to induce upregulation of genes associated with osteoblast activity-interleukin 11 (IL-11), osteopontin (OPN), and alkaline phosphatase (ALPL) and that the kinetics of the induction and the G protein-mediated signaling pathways involved were different for these genes ...

Proteintech的Human IL-11 ELISA Kit （货号KE00273）具有极高的灵敏度，可以检测低至0.1 pg/mL的IL-11， 线性范围宽（6.25-400 pg/mL），可以方便地检测血浆、血清或者细胞上清中IL-11的含量。

2016年3月7日 · We demonstrated that TSH-induced up-regulation of IL-11 is primarily mediated via the Gs pathway as IL-11 was up-regulated by forskolin (FSK), an adenylyl cyclase activator, and inhibited by protein kinase A inhibitor H-89 and by silencing of Gαs by small interfering RNA.

siRNA inhibited TSH-mediated upregulation of IL-11 as well as basal IL-11 expression, most likely due to inhibition of TSHR’s constitutive Gαs-mediated signaling activity. By contrast, we found that OPN induction by TSH was independent of the Gαs pathway as neither FSK nor H-89 had a significant effect. OPN induction was slower than that ...

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2024年7月17日 · Here we examined whether IL-11, a pro-inflammatory cytokine of the IL-6 family, has a negative effect on age-associated disease and lifespan. As mice age, IL-11 is upregulated across cell...

2023年12月1日 · Interleukin- (IL)-11 is a cytokine involved in hematopoiesis, cancer metastasis, and inflammation. IL-11 belongs to the IL-6 cytokine family, binding to the complex of receptors glycoprotein gp130 and the ligand-specific-receptor subunits (IL-11Rα or …

2020年5月19日 · We review our findings that TSHR couples to several different G proteins to induce upregulation of genes associated with osteoblast activity—interleukin 11 (IL-11), osteopontin (OPN), and alkaline phosphatase (ALPL) and that the kinetics of the induction and the G protein-mediated signaling pathways involved were different for these genes ...

2023年9月22日 · In TED, the TSHR cross talks with the insulin-like growth factor 1 receptor (IGF-1R) in orbital fibroblasts leading to inflammation, deposition of hyaluronan and adipogenesis. The bone marrow may play an important role in autoimmune diseases, but its role in Graves’ disease and TED is unknown.

Interleukin 11 (IL11) is an elusive member of the IL6 family of cytokines. While initially thought to be a haematopoietic and cytoprotective factor, more recent data show instead that IL11 is redundant for haematopoiesis and toxic.