2019年4月16日 · The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 th anniversary of its discovery.

Interleukin-17 (IL-17, also known as IL-17A) is a key cytokine that links T cell activation to neutrophil mobilization and activation. As such, IL-17 can mediate protective innate immunity to pathogens or contribute to the pathogenesis of ...

2024年3月22日 · IL-17 inhibitors block the inflammatory pathway of interleukin-17A. These biologic medications are an extremely effective FDA-approved treatment option for people with psoriasis and psoriatic arthritis.

2023年10月11日 · Interleukin 17 (IL-17) is an important cytokine that has several roles in host defense responses against mucosal infections; additionally, it is a primary pathologic cytokine and therapeutic...

2025年3月21日 · Panelists discuss how IL-17 inhibitors differ in their targets within the IL-17 pathway. Secukinumab and ixekizumab block IL-17A, reducing inflammation in psoriasis and arthritis. Brodalumab inhibits IL-17RA, affecting multiple IL-17 cytokines, but carries suicide risk warnings. Bimekizumab targets IL-17A and IL-17F, potentially enhancing efficacy but with …

2024年12月25日 · IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Interleukin-17A (IL-17A) is the signature cytokine of a subset of CD4 + helper T cells known as Th17 cells (McGeachy et al., 2019). The feature of Th17 cells is the expression of the RAR-related orphan receptor γ (RORγt) transcription factor (Ivanov et al., 2006).

2025年2月8日 · IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

5 天之前 · HSD promoted IL-17A production in mice. (A, B) Representative and quantified flow cytometry of IL-17A-producing cells by total lymphocytes in the spleen, peripheral blood, and brain tissues of HSD ...

This article reviews the mechanism of action of IL-17A and the application of anti-IL-17A antibodies, focusing on the research progress on the mechanism of action and therapeutic blockade of IL-17A in various tumors such as colorectal cancer (CRC), lung cancer, gastric cancer and breast cancer.