白介素2(IL-2)相关细胞因子及生物学功能 - 知乎
il-2是肿瘤浸润淋巴细胞的关键生长因子，该细胞可与il-2在体外一起扩增，用于治疗性回输给患者。通过平衡il-2的量或通过使用新的il-2类似物与il-2特异性抗体组合，可以平衡t细胞反应，控制效应细胞的扩增。 此外，il-2调节cd4+ th细胞亚群的分化。
The Presence and Pathogenic Roles of M(IL-33 + IL-2 ... - PubMed
2024年12月13日 · Using Lyz-ST2KO mice and adoptive transfer of M (IL-33 + IL-2), we found that M (IL-33 + IL-2) significantly promoted pathogenesis in OVA-induced allergic airway inflammation. M (IL-33 + IL-2) has a distinctive gene expression profile with high expression of IL-9, IL-5, and IL-13 and its polarization is dependent on JAK2-STAT3-IRF1 pathway.
Human IL-2Rɑ subunit binding modulation of IL-2 through a
2022年2月25日 · Pulmonary edema is caused by direct binding of IL-2 with the functional form of IL-2 receptors (IL-2Rαβγc) on lung endothelial cells and blocking the a-chain leads to dramatically reduction of the pulmonary toxicity induced by IL-2 .
Cell Reports丨巨噬细胞极化机制的全局特征和 M2 型极化抑制剂的 …
2023年9月22日 · 作者对转录组研究和先前报告的通路分析表明，pi3k/akt 信号促进 m2 型极化（图 4a），作者发现 il-4 诱导 pi3k 的 p85α 亚基（y467 和 y580）和 akt1（s124、s126 和 s129）的激活，在 il-4 处理后 30 分钟至 1 小时达到峰值（图 5b）。
干货分享/巨噬细胞极化 - 丁香园论坛
m1型巨噬细胞在促炎因子如lps和ifn-γ的作用下极化，高表达il-12和il-23，产生大量的tnf-α、il-6等致炎因子，促进炎症反应和病原体清除。而m2型巨噬细胞则在抗炎因子如il-4和il-13的作用下极化，高表达il-10和tgf-β，促进炎症消退和组织修复。
Cell Reports 丨M1&M2 巨噬细胞极化的转换 - 知乎 - 知乎专栏
2023年6月14日 · 证实我们对小鼠巨噬细胞的研究，人类 m1 巨噬细胞显示出严重受损的 il-4 诱导的 m2 标记基因 ccl22、ccl24、cd200r、cd206 和 fcer2 (cd23) 的表达（图 2b）。因此，m2 表面标记 cd23、cd200r 和 cd206 在之前的 lps + ifnγ 刺激后未被 il-4 诱导（图 2c）。
IL-2-loaded liposomes modified with sorafenib derivative exert a ...
2025年1月10日 · IL-2-So-Lipo, a targeted IL-2 delivery system via liposome modified with polyethylene glycol and sorafenib derivative, is capable of significantly inhibiting the growth of melanoma, mitigating angiogenesis and promoting the infiltration of CD8 + T cells and M1 polarization of macrophages within the tumor. The diagram is created using BioRender. 1.
Circulating IL6 is involved in the infiltration of M2 ... - Nature
5 天之前 · Notably, the infiltration of M2 macrophages and CD8 + T cells exhibited significant correlations with the levels of IL-6 and IL-2. Specifically, M2 macrophage and CD8 + T cell infiltration showed ...
The Presence and Pathogenic Roles of M(IL‐33 + IL‐2) …
2024年12月13日 · Using Lyz-ST2KO mice and adoptive transfer of M (IL-33 + IL-2), we found that M (IL-33 + IL-2) significantly promoted pathogenesis in OVA-induced allergic airway inflammation. M (IL-33 + IL-2) has a distinctive gene expression profile with high expression of IL-9, IL-5, and IL-13 and its polarization is dependent on JAK2-STAT3-IRF1 pathway.
Roles for macrophage-polarizing interleukins in cancer immunity …
2022年5月19日 · IL-2 stimulates the formation of DCs and promotes macrophage polarity toward the M1 phenotype . In fact, the impact of IL-2 on tumor exclusion is mediated through promoting the effector activity of a number of cells including macrophages and CD8 + T cells through inducing differentiation of effector CD8 + T cells. These cells are also ...