The common gamma chain (γ c) (or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, [5] IL-7, [6] IL-9, IL-15 [7] and interleukin-21 receptor.

Hundreds of variants (also known as mutations) in the gene have been identified in people with X-linked severe combined immunodeficiency (SCID). This condition is an inherited disorder of the immune system that occurs almost exclusively in males.

2024年12月25日 · IL2RG (Interleukin 2 Receptor Subunit Gamma) is a Protein Coding gene. Diseases associated with IL2RG include Severe Combined Immunodeficiency, X-Linked and Combined Immunodeficiency, X-Linked. Among its related pathways are IL-9 Signaling Pathways and Interleukin-2 family signaling.

Data indicate a nonsense mutation in exon 8 (p.R328X) of interleukin (IL)-2 receptor common gamma chain gene (IL2RG)in two brothers were diagnosed with X-Linked combined Immunodeficiency (X-SCID). High IL2RG expression is associated with peripheral Tcell lymphoma expressing the ITKSYK fusion gene.

1 天前 · The IL-2 receptor gamma subunit (IL-2Rγ or CD132) is an essential signaling component shared by multiple cytokine receptors, including those for IL-4, IL-7, IL-9, IL-15, and IL-21. This common gamma chain is crucial for signal propagation, as it associates with JAK3 to initiate downstream pathways like STAT5 phosphorylation.

2025年2月8日 · The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain.

IL2RG is a gene that encodes the interleukin-2 (IL-2) receptor gamma chain, also known as the common gamma chain (γc) or CD132. Mutations in this gene can cause X-linked severe combined immunodeficiency (XSCID), which is the most common genetic form of SCID.

Hundreds of variants (also known as mutations) in the IL2RG gene have been identified in people with X-linked severe combined immunodeficiency (SCID). This condition is an inherited disorder of the immune system that occurs almost exclusively in males.

2025年1月4日 · Title: IL-2RG as a possible immunotherapeutic target in CRC predicting poor prognosis and regulated by miR-7-5p and miR-26b-5p. PD-1 signaling negatively regulates the common cytokine receptor gamma chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity.

The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of i nterleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less ...