2018年9月5日 · In contrast to IL-6 classic signaling, IL-6 trans-signaling induces the release of the pro-inflammatory chemokine Monocyte Chemoattractant Protein-1 (MCP-1) from human vascular endothelial cells. In addition, we reveal that the classic signaling induces activation of the JAK/STAT3 pathway while trans-signaling also activates the PI3K/AKT and ...

2008年4月1日 · Interleukin-6 (IL6) is a growth and survival factor in human prostate cancer (PCa) cells with aggressive phenotypes and has been implicated in the progression of hormone refractory PCas. In the present study, we characterized the IL6-triggered PI3K/Akt and MAPK/Erk signaling. We identified the A-typ …

2018年9月5日 · Furthermore, we demonstrate that MCP-1 induction by IL-6 trans-signaling requires simultaneous activation of the JAK/STAT3 and PI3K/AKT pathways. Collectively, our study reports molecular differences in IL-6 classic- and trans-signaling in human vascular endothelial cells; and elucidates the pathways which mediate MCP-1 induction by IL-6 trans ...

Here we describe a novel role for the phosphatidylinositol 3-kinase/AKT pathway in mediating induction of interleukin-6 (IL-6) in response to IL-1. Pharmacological inhibition of phosphatidylinositol 3-kinase (PI3K) inhibited IL-6 mRNA and protein production.

IL-6结合受体有两种，一种是特异性受体 IL-6R （80kDa I型跨膜蛋白），另一种是gp130，是IL-6家族细胞因子的所有成员的常见受体亚单位。gp130可以在所有细胞表达，但IL-6R的表达受到更多的限制，主要发现于肝细胞、嗜中性粒细胞、单核细胞和CD4+ T细胞。

IL-6 信号转导异常参与了自身免疫疾病、炎症和部分癌症（如前列腺癌和多发性骨髓瘤）的发病机理。 目前 Jak 抑制剂在多发性骨髓瘤模型中进行测试。 Stat3 可充当一种致癌基因，并在许多肿瘤中持续激活。 在某些癌细胞中可见细胞因子信号转导和 EGFR 家族成员的交互作用。 研究发现在 EGFR 过表达的胶质瘤细胞中，Jak2 结合到 EGFR 上的 FERM 结构域可诱导对 EGFR 激酶抑制剂的抗性 [Sci. Signal. (2013) 6, ra55]。 在人类血液恶性肿瘤中，Jak 突变激活为主要分子事 …

PI3K-Akt信号通路是细胞中一个关键的信号传导网络，它可被多种细胞刺激或毒性损伤所激活，并在调控转录、翻译、增殖、生长和存活等基本细胞功能中扮演重要角色。 当生长因子与细胞膜上的 受体酪氨酸激酶 （RTK）或 G蛋白偶联受体 （GPCR）结合时，它们会分别刺激Ia和Ib类PI3K同工酶。 这些被激活的PI3K在细胞膜上催化磷脂酰肌醇，产生第二信使分子—— 磷脂酰肌醇-3,4, 5-三磷酸酯 （PIP3）。 PIP3随后作为关键分子，帮助激活Akt（蛋白激酶B）。 一旦Akt被激活， …

It is reported that IL-6 has a protective effect on neuronal cells through the JAK/STAT3, MAPK/ERK and PI3K/AKT signaling pathways. 29 In addition, IL-6 increased autophagy in vitro in a dose-dependent manner and activated the JAK-STAT pathway to induce cardioprotective autophagy and signaling. 30 IL-6-induced activation of STAT3 or STAT5 is a ...

2019年8月13日 · Results: Studies of three IL-6-blockade refractory iMCD cases revealed increased CD8+ T cell activation, VEGF-A, and PI3K/Akt/mTOR pathway activity. Administration of sirolimus significantly attenuated CD8+ T cell activation and decreased VEGF-A levels.

2023年9月21日 · Our model quantitatively characterized the effects of IL-6 classic and trans-signaling in activating the signal transducer and activator of transcription 3 (STAT3), phosphatidylinositol...