IL-6是一种具有多效活性的细胞因子，可以促进多种细胞的增殖和分化，也可以加速肝细胞 急性期蛋白 的合成，还可以抑制M1髓性白血病细胞系的生长，促进其成熟和分化，抑制黑素瘤、乳腺癌细胞的生长。

IL-6作为抗炎性肌动蛋白的作用是通过其对 TNF-α 和 IL-1 的抑制作用以及 IL-1ra 和 IL-10 的激活而介导的。 早期证据表明，在更广泛的冠状病毒大流行的背景下，IL-6可以用作严重COVID-19感染的炎性标志物，预后较差。 IL-6通过细胞表面I型细胞因子受体复合物发出信号，该复合物由结合配体的IL-6Rα链（CD126）和信号转导成分gp130（也称为CD130）组成。 CD130是多种细胞因子的常见信号转导子，包括 白血病抑制因子 （LIF）， 睫状神经营养因子，IL-11和 心肌钙蛋 …

We investigated the role of human interleukin-6 (IL-6) in the regulation of the third component of complement (C3) biosynthesis by cultured rat liver epithelial cells. A natural human IL-6 (nh IL-6) preparation was shown to up-regulate C3 production, whereas an Escherichia coli-derived recombinant h …

IL-6 plays a key role in the development of autoimmune heart disease, possibly by upregulating complement C3. IL-6 KO mice with autoimmune myocarditis showed a reduction in inflammatory responses, the proliferation of autoreactive CD4+ T cells, and the expression of ICAM-1 and VCAM-1, which reduced myocarditis susceptibility ( 155 ).

Here we report that in fibroblasts, IL 6 induces increases in the rate of synthesis of factor B and C3, activator proteins of the alternative pathway of complement activation. The increases in factor B and C3 were concentration dependent reaching about 40- and 15-fold, respectively.

白细胞介素-6 (IL-6)是一种重要的促炎细胞因子，在感染或组织损伤过程中释放，促进先天和获得性免疫反应。 IL-6由天然免疫细胞，如巨噬细胞，在遇到损伤相关分子模式 (DAMP)或病原体相关分子模式 (PAMPs)后迅速表达，作为宿主防御策略的一部分，以清除感染细胞或受损组织。 然而过度产生IL-6可导致慢性炎症性疾病的发展（如 类风湿性关节炎）以及细胞因子风暴，其发生于 CAR-T治疗 的患者以及感染新冠病毒 SARS-CoV-2 等在内的各种疾病。 人类 IL-6 基因位于第 …

2005年4月21日 · IL-1β and IL-6 demonstrated synergy with respect to the quantity and rate of increase of C3 mRNA measured and the magnitude of C3 protein secretion. Previous reports using non-rat cytokines did not consistently predict H-35 responses to rat cytokines.

2018年4月1日 · C3 significantly counteracted the effects of IL-6 in reducing p-eNOS expression and increasing the expression of MMP-9, ICAM-1 and VCAM-1 (Fig. 3 B). In addition, inhibition of RhoA activity by C3 significantly neutralized the elevated levels of sICAM-1 and sVCAM-1 by IL-6 in conditioned media from the above cell culture ( Fig. 3 C).

2005年4月21日 · IL-1beta and IL-6 demonstrated synergy with respect to the quantity and rate of increase of C3 mRNA measured and the magnitude of C3 protein secretion. Previous reports using non-rat cytokines did not consistently predict H-35 responses to rat cytokines.

2020年1月13日 · We employed CR1 to block exogenous activation of C3 and detected a weakened expression of p-STAT3 and IL-6 compared with AG490-treated cancer cells (Fig. 7c). These data indicated that localized activation and deposition of C3 may play a role in tumor growth and metastasis by potentiating JAK2/STAT3 activation (Fig. 7 d).