CD5: A New Partner for IL-6 - Cell Press
2016年4月19日 · In this issue of Immunity, Yu and colleagues (2016) show that IL-6-binding CD5, rather than IL-6 receptor-α in B cells, amplifies STAT3 activation via JAK-STAT signaling to …
CD5 binds to Interleukin-6 and induces a feed-forward loop with …
2016年4月4日 · Our results demonstrate that CD5 bound and responded to IL-6, which activated STAT3 by gp130 and JAK2 in B cells in tumor microenvironment. Furthermore, STAT3 …
CD5: A New Partner for IL-6 - ScienceDirect
2016年4月19日 · IL-6 binds to CD5 on B cells, which in turn leads to the CD5-gp130 interaction, and thereby activates the downstream JAK-STAT signaling. STAT3 activation stimulates the …
Science | 表达CD5的树突状细胞指导T细胞免疫并维持免疫治疗应 …
2023年3月1日 · 在经抗PD-1治疗的小鼠TME中检测到免疫细胞产生的IL-6分泌量增加（图6G）。进一步研究发现，IL-6有利于小鼠骨髓祖细胞分化为CD5+ DC（图6，H和I），高浓度的IL …
CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop
2016年4月19日 · Here, we demonstrate that the proportion of CD5(+) relative to interleukin-6 receptor α (IL-6Rα)-expressing B cells was greatly increased in tumors. CD5(+) B cells …
IL-6 modulates CD5 expression in B cells from patients with ... - PubMed
2009年5月1日 · The study reveals that engagement of the BCR with constitutive IL-6 down-regulates the level of membrane CD5, which negatively regulates BCR signaling, in SLE B …
CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with …
Yu and colleagues demonstrate that CD5 binds to IL-6 and induces STAT3 activation in the absence of IL-6Rα in B cells. In mouse tumor models, CD5+ but not CD5– B cells promote …
IL-6 binds to CD5 on B cells, which in turn leads to the CD5-gp130 interaction, and thereby activates the downstream JAK-STAT signaling. STAT3 activation stimulates the transcription …
CD5: A New Partner for IL-6 - PubMed
2016年4月19日 · In this issue of Immunity, Yu and colleagues (2016) show that IL-6-binding CD5, rather than IL-6 receptor-α in B cells, amplifies STAT3 activation via JAK-STAT signaling to …
CD5: from antiquated T cell marker to immunotherapy’s new hope
2023年5月25日 · The role of CD5 in tumor immunology and therapeutic chances. a CD5 + cDC2 play an important role in tumor immunology. (upper left) Under influence of IL-6, hematopoietic …