An International Life Sciences Institute (ILSI) – Europe expert group has examined this TTC principle for its applicability to food safety evaluation. This monograph describes the history and development of the principle and its application to chemicals in …

Develop scientific approaches for refinement of TTC-based co-exposure risk assessments, using real-world case examples and focus on data-poor substances and poorly characterized compounds at low exposure levels (metabolites/impurities of pesticides, chemicals, or biocides, food contact material migrants, packaging materials, or process-related ...

2017年9月1日 · TTC 被定义为 ：针对所有化学物质的一个暴露水平，当低于该暴露水平时，无论是否获得化学特异性的毒性数据，在终身服用的情况下对人体健康都不会产生明显的危害。

2004年1月1日 · The Thresholds of Toxicological Concern (TTC) is a pragmatic risk assessment tool that is based on the principle of establishing a human exposure threshold value for all chemicals, below which there is a very low probability of an appreciable risk to human health.

2004年1月1日 · An Expert Group of the Threshold of Toxicological Concern Task Force of the European branch of the International Life Sciences Institute (ILSI Europe) has examined the TTC principle, which was based on general toxicity endpoints (including carcinogenicity), in relation to its applicability in food safety evaluation.

Structure-Based Thresholds of Toxicological Concern (TTC): Guidance for Application to Substances Present at Low Levels in the Diet

2023年5月23日 · 毒理学关注阈值 （Threshold of Toxicological Concern，简称TTC），在《化妆品安全评估技术导则》 [1]中定义是这样的：化妆品暴露阈值，在该暴露水平下，预计不存在危害人类健康的风险。

国际药用气雾剂联盟 (International PharmaceuticalAerosol Consortium，IPAC)采纳了TTC方法对药物中的低水平存在的化学物质，如包装材料引入的迁移物，进行风险评估和质控。

The threshold of toxicological concern (TTC) is a pragmatic risk assessment tool that is based on the principle of establishing a human exposure threshold value for all chemicals, below which there is a very low probability of an appreciable risk to human health.

2002年2月28日 · An International Life Sciences Institute (ILSI)-Europe expert group has examined this TTC principle, which was based on general toxicity endpoints (including carcinogenicity), for its applicability in food safety evaluation.