Inosine 5′-monophosphate dehydrogenase (IMPDH) is a purine biosynthetic enzyme that catalyzes the nicotinamide adenine dinucleotide (NAD +)-dependent oxidation of inosine monophosphate (IMP) to xanthosine monophosphate (XMP), the first committed and rate-limiting step towards the de novo biosynthesis of guanine nucleotides from IMP.

IMP可被次黄嘌呤核苷酸脱氢酶（IMPDH）氧化生成黄嘌呤，再由鸟苷酸合成酶（GMPS）催化，接受谷氨酰胺的氨基，生成GMP。 AMP与GMP的合成是互相影响的。 ADSS需要GTP，而GMPS又需要ATP。 这导致其中一种NTP的积累会消耗自身来加速另一种的合成，最后使二者浓度接近。 这也是细胞调控核苷酸平衡的手段之一。 嘌呤核苷酸的补救途径主要涉及3个酶，腺苷激酶（ADK）、腺嘌呤磷酸核糖转移酶（APRT）和次黄嘌呤-鸟嘌呤磷酸核糖转移酶（HGPRT） …

2016年11月3日 · 次黄嘌呤单核苷酸脱氢酶（impdh）是一种鸟嘌呤从头合成途径的限速酶，在细胞增殖过程中发挥着重要作用。目前临床常用的作用于impdh的药物为impdh抑制剂，主要应用于抗免疫排斥、抗肿瘤、抗病毒或抗寄生虫等领域。

IMPDH is a purine biosynthetic enzyme that catalyzes the conversion of inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP). The abnormal expression of IMPDH is closely related to cancer and autoimmune diseases.

IMPDH controls the gateway to guanine nucleotides, making it an “enzyme of consequence” for virtually every organism. IMP is the product of de novo purine nucleotide biosynthesis and the precursor to both adenine and guanine nucleotides . The IMPDH-catalyzed conversion of IMP to XMP is the first committed and rate-limiting step in guanine ...

2012年7月13日 · Inosine monophosphate dehydrogenase (IMPDH) controls the guanine nucleotide pool and, thereby, cell proliferation. We found that Drosophila IMPDH is also a DNA-binding transcriptional repressor. IMPDH attenuates expression of histone genes and E2f, a key driver of cell proliferation.

Inosine-5'-monophosphate dehydrogenase (IMPDH) is an enzyme involved in the de novo biosynthesis of guanine nucleotides. To date human IMPDH inhibitors have been approved for prevention of organ transplant rejection and as anti-viral agents.

1996年6月14日 · The structure of inosine-5′-monophosphate dehydrogenase (IMPDH) in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction. IMPDH plays a central role in B and T lymphocyte replication.

Inosine-5′-monophosphate dehydrogenase (IMPDH) is a highly conserved enzyme in purine metabolism that is tightly regulated on multiple levels. IMPDH has a critical role in purine biosynthesis, where it regulates flux at the branch point between ...

肌苷单磷酸脱氢酶（impdh）是嘌呤核苷酸从头合成的关键酶，被视为在抗病毒，抗菌和抗癌治疗领域中寻找药物的重要靶标。这篇综述着重于impdh的药物化学，药物发现和化学生物学。提供了imp和辅因子定点抑制剂，变构抑制剂和同工型选择性抑制剂的实例。