2018年12月11日 · To address common H3.3 point mutations, we have generated data from GCTB patient samples with H3.3 G34W substitutions and engineered human GFP-tagged H3.3-mutated isogenic cell lines for high...

2025年3月30日 · H3-3B (H3.3 Histone B) is a Protein Coding gene. Diseases associated with H3-3B include Bryant-Li-Bhoj Neurodevelopmental Syndrome 2 and Bryant-Li-Bhoj Neurodevelopmental Syndrome. Among its related pathways are RNA Polymerase I Promoter Opening and Assembly of the pre-replicative complex. An important paralog of this gene is H3-3A.

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Full gene name according to HGNC. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Assigned HPA protein class (es) for the encoded protein (s). Number of protein-coding transcripts from the gene as defined by Ensembl.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes.

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2017年5月18日 · We propose that H3.3 prevents recruitment of H1, inhibiting H1’s promotion of chromatin folding that restricts access to DNA methyltransferases responsible for gene body methylation. Thus, gene body methylation is likely shaped by H3.3 dynamics in conjunction with transcriptional activity.