2023年8月21日 · In this paper, we proposed a consensual machine-learning technique-based prediction approach to identify disease-related miRNAs and lncRNAs by high-order proximity preserved embedding (HOPE) and eXtreme Gradient Boosting (XGB), named HOPEXGB.

High-performance network visual analytics: miRNet allows users to easily create miRNA-centric networks consisting of different molecules or phenotypes of interest: genes, diseases, small molecules, SNPs (affecting miRNAs or their binding sites), ncRNAs (lncRNA, sncRNA, circRNA or peudogene), epigenetic modifiers, and transcription factors. The ...

2023年8月3日 · Specifically, BCMCMI utilizes the bidirectional encoding capability of the BERT algorithm to extract sequence features from the semantic information of circRNA and miRNA. Then, a heterogeneous network is constructed based on …

2018年7月13日 · We present a novel approach for miRNA target prediction based on Deep Learning (DL) which, rather than incorporating any knowledge (such as seed regions), investigates the entire miRNA and 3’TR mRNA nucleotides to learn a uninhibited set of feature descriptors related to the targeting process.

2022年6月23日 · We developed a deep learning tool called DMISO to capture the intricate features of miRNA/isomiR–mRNA interactions. Based on tenfold cross-validation, DMISO showed high precision (95%) and recall...

2016年7月20日 · Here, we present a model to predict miRNA-mRNA interactions solely based on their sequences, using new technologies to map AGO and miRNA binding interactions with machine learning techniques. Our algorithm produces more accurate predictions than state-of-the-art methods based on indirect measurements.

2023年1月3日 · As a kind of non-coding RNA transcript, MicroRNA (miRNA) plays a vital role in cell proliferation, survival and differentiation by modulating the transcription of target messenger RNA (mRNA) and disrupting the translation of mRNA (Rupaimoole and Slack, 2017).

2024年6月5日 · In this paper, a miRNA-Disease association prediction model (called TP-MDA) based on tree path global feature extraction and fully connected artificial neural network (FANN) with multi-head self-attention mechanism is proposed.

2021年9月26日 · It is a common practice to analyze miRNA PCR Array data using the commercially available software, mostly due to its convenience and ease-of-use. In this work we present miRkit, an open source framework written in R, that allows for the comprehensive analysis of RT-PCR data, from the processing of raw data to a functional analysis of the ...

2016年3月24日 · Based on the biological characteristics of miRNA and isomiR, we developed miR-isomiRExp to analyze expression pattern of miRNA at the miRNA/isomiR levels, provide insights into tracking miRNA/isomiR maturation and processing mechanisms, and reveal functional characteristics of miRNA/isomiR.