2023年11月21日 · These results suggest that PTK2B directly interacts with TBK1 and STING, and potently regulates STING-TBK1 signaling. In addition, Co-IP results indicated that TBK1, but not RIG-I and MAVS,...

2015年1月29日 · These signals activate the protein kinase TBK1 and the transcription factor IRF3, which tells cells to secrete interferon proteins (IFNs) important for host defense. Liu et al. now report a common signaling mechanism used by all three types of innate immune receptor-adaptor protein pairs to activate IRF3 and generate IFNs.

2023年6月23日 · TBK1 is the downstream of MAVS and the negative regulation of VANGL2 to IFN-I at MAVS relies on TBK1, so we mainly focused on the effect that VANGL2 targets on TBK1. Endogenous co-IP assay showed the interaction between VANGL2 and TBK1 enhanced after VSV infection in BMDMs and A549 cells (Fig. 3D and fig. S3, A to C).

2025年2月11日 · a IP-mass spectrometry (MS) from 786-O and Caki-1 tumor lysates identified TBK1 as a top candidate protein interacting with BBOX1. b List of top BBOX1 binding proteins identified by IP-MS from 786 ...

TANK-binding kinase 1 (TBK1) and its homolog IKKε are serine/threonine kinases mediating type I interferon (IFN-I) induction and antiviral innate immunity 1.

TANK-binding kinase 1 (TBK1) is a key kinase in regulating antiviral innate immune responses. While the oligomerization of TBK1 is critical for its full activation, the...

为了研究sting如何结合tbk1，研究人员分析了sting c-末端和tbk1复合物的晶体结构。 结构表明STING的PLPLRT/SD 模块结合在TBK1二体的表面上。 需要说明的是，在研究人员投稿三周后，达拉斯西南医学中心的陈志坚博士也向 Nature 投稿，报告他们用 冷冻电子显微镜 测定的 ...

Monoclonal antibody is prepared from animals immunized with a synthetic phosphopeptide corresponding to residues surrounding Ser172 of human TBK1. TBK1 (TANK-binding kinase 1)/NAK (NF-κB activating kinase) is an IκB kinase (IKK)-activating kinase and can activate IKK through direct phosphorylation (1).

2024年12月24日 · Immunoprecipitation (IP) of TBK1 from bone marrow-derived macrophages (BMDMs) revealed a significant increase in succinylation after 24 h of LPS treatment (Figure 1 E). Similar results were observed in LPS-treated and untreated murine alveolar macrophages (MHSs) and human macrophages (THP-1) in vitro (Figures S1 A and S1B).

TBK1激酶通过介导 天然免疫 和 自噬 消除入侵的病原体，同样，TBK1介导的天然免疫信号的慢性激活可以对宿主启动免疫攻击，导致器官损伤和疾病；因此，TBK1被认为是治疗炎症和自身免疫性疾病的潜在靶点。 TBK1的结构和活化机制. 人体的TBK1激酶由745个氨基酸组成，包括N末端激酶结构域 (KD)、泛素样结构域 (ULD)、α-螺旋二聚化结构域 (SDD)和C末端接头结合结构域 (CTD)（图1a）。 KD、ULD和SDD之间的广泛相互作用形成了一个紧凑的TBK1二聚体。 …