‌IP3（inositol triphosphate， 三磷酸肌醇）是一种肌醇磷酸信号分子，是参与 G蛋白 耦联受体介导的信号转导的第二信使。 在 磷脂酰肌醇 途径中，胞外 信号分子 与其相应的G蛋白偶联受体结合后，激活膜上的Gq蛋白（一种作用于磷脂酰 肌醇 系统的G蛋白），然后由Gq蛋白激活 磷酸酯酶 Cβ （phospholipase Cβ， PLC）， 将膜上的4，5-二 磷酸 脂酰肌醇（phosphatidylinositol biphosphate， PIP2）分解为两个细胞内的 第二信使： DAG和IP₃，最后通过激活 蛋白激酶C …

Inositol trisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP3 or Ins3P or IP3 is an inositol phosphate signaling molecule. It is made by hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP 2), a phospholipid that is located in the plasma membrane, by phospholipase C …

Here, we review the role of IP3 as an intracellular and intercellular cell death messenger, focusing on the endoplasmic reticulum-mitochondrial synapse, followed by a discussion of plausible elements that can convert IP3 from a physiological molecule to a killer substance.

Inositol 1,4,5-trisphosphate receptors (IP 3 Rs) are large tetrameric channels which sit mostly in the membrane of the endoplasmic reticulum (ER) and mediate Ca 2+ release from intracellular stores in response to extracellular stimuli in almost all cells.

Three IP 3 R isoforms are responsible for the generation of intracellular Ca 2+ signals that may spread across the entire cell or occur locally in so-called microdomains. Because of their ubiquitous expression, these channels are involved in the regulation of a plethora of cellular processes, including cell survival and cell death.

在这里，我们报告了人类 3 型 IP 3 R的低温电子显微镜 (cryo-EM) 结构，该结构从多个门控构象的单个数据集中获得：IP 3 -ATP 与封闭通道结合的前激活状态，IP 3 -ATP-Ca 2+ 与开放通道结合的激活状态，以及 IP 3 -ATP-Ca 2+ 与封闭通道结合的非激活状态。 这些结构展示了 IP 3 诱导的构象变化如何引发受体被 Ca 2+激活，Ca 2+ 结合如何导致通道开放，以及 ATP 如何调节活性，从而深入了解有关分子机制基础的长期探索问题受体激活和门控。

• Initial Guidelines for using DDS with MESH – How many parameters should I calibrate with DDS? • however many you would have tried changing during manual

2022年3月17日 · Here we report cryo-electron microscopy (cryo-EM) structures of human type-3 IP 3 R obtained from a single dataset in multiple gating conformations: IP 3 -ATP bound pre-active states with...

6-(ortho-nitroveratryl)-caged IP3 MeSH Supplementary Concept Data 2025. Details; Concepts

The inositol 1,4,5-trisphosphate (IP 3) receptor (IP 3 R) is a ubiquitously expressed Ca 2+ -release channel localized in the endoplasmic reticulum (ER).