2025年1月21日 · D. L. Mallery et al., Cellular IP6 levels limit HIV production while viruses that cannot efficiently package IP6 are attenuated for infection and replication. Cell Rep.29, …

2005年9月2日 · We report the crystal structure of the catalytic domain of human ADAR2, an RNA editing enzyme, at 1.7 angstrom resolution. The structure reveals a zinc ion in the active site …

2025年1月21日 · The importance of IP6 for ADAR RNA-editing enzymes and antiviral defense

Another mechanism by which ADAR1 could be modulated during viral infection is by regulating the availability of a free inositol pyrophosphate (IP6). IP6 may regulate ADAR1 as it is an …

Additionally, the presence of IP6 in the CDD is essential to ADAR catalytic activity. The necessity of the IP6 binding has been useful for potential ADAR therapies where the IP6 binding cavity …

2024年11月29日 · 针对磷酸肌醇生物合成途径的进一步探索，揭示了肌醇五磷酸2激酶IPPK-1/IPPK产生的IP6具有通过腺苷脱氢酶ADAR 抑制RNAi反应的功能（图1）。 在ADAR介导 …

该研究在识别介导线粒体功能障碍监测的调控因子的遗传筛选中，意外地发现了肌醇多磷酸多激酶 IPMK/IPMK-1（inositol polyphosphate multikinase）突变体增强了RNAi介导的外源遗传元件的 …

We report the crystal structure of the catalytic domain of human ADAR2, an RNA editing enzyme, at 1.7 angstrom resolution. The structure reveals a zinc ion in the active site and suggests how …

2025年1月21日 · IP6 对 ADAR RNA 编辑酶和抗病毒防御的重要性。 Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2025-01-21 , DOI: …

The importance of IP6 for ADAR RNA-editing enzymes and antiviral defense. Proceedings of the National Academy of Sciences of the United States of America ( IF9.4 ) Pub Date : 2025-01 …