Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease that is characterized by replacement of the normal lung anatomy with active remodeling and deposition of extracellular matrix (ECM) accompanied by a shift in lung cellular communities. The most common outcome of this debilitating disease is respiratory failure and subsequent death.

Histopathological characteristics of IPF include excessive deposition of the extracellular matrix (ECM), leading to distortion of normal lung architecture and irreversible loss of lung function (Glass et al., 2020). IPF is clinically manifested by progressive dyspnea and a significant decrease in lung compliance (Schafer et al., 2020).

2020年7月8日 · We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 chronic obstructive pulmonary disease (COPD) lungs. Among epithelial cells enriched in IPF, we identify a previou …

2025年3月27日 · Rutgers Health researchers have discovered that networks of misplaced immune cells drive an aggressive lung disease, potentially opening a path to new treatments for a condition that kills 80% of patients within a decade. Idiopathic pulmonary fibrosis (IPF) scars lung tissue and makes breathing ...

2025年4月1日 · Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial lung disease with a complex pathogenesis involving multiple immune cells. This study investigates the relationship between immune cells and IPF using Mendelian randomization (MR) analysis.

2020年12月1日 · 1 Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut. 2 Interdepartmental Program in Computational Biology and Bioinformatics, Yale University School of Medicine, New Haven, Connecticut. Keywords: IPF; data sharing; single-cell RNAseq; systems biology.

2024年10月21日 · Evidence suggests that IPF arises from genetic, environmental, and aging-related factors. The pathogenic mechanisms of IPF primarily involve dysregulated repeated microinjuries to epithelial...

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung disease of unknown aetiology, characterised by limited treatment options and a high mortality rate [1, 2, 3, 4, 5]. Despite its variable and unpredictable course, the median survival time following diagnosis is only 2–4 years [6].

2025年2月20日 · Distinct subsets of IPF-associated mural cells and fibroblasts promote pathological plasma cell and antibody accumulation. These findings have potential implications for strategies aimed at targeting immune and antibody responses to combat IPF.

2024年8月1日 · In an identifiable population of immune cells, we found increased percentage of CD8 + T cells in the T cell subpopulation in IPF. Monocle analyzed the dynamic immune status and cell transformation of CD8 + T cells, as well as the cytotoxicity and exhausted status of CD8 + T cell subpopulations at different stages.