诱导多能干细胞（Induced Pluripotent Stem Cells，简称iPSC）是一类通过特定的基因重编程技术，将体细胞（如皮肤细胞、血细胞等）转化为具有类似胚胎干细胞（Embryonic Stem Cells，ESC）特性的多能性细胞。 这些多能细胞能够分化为三胚层（内胚层、中胚层和外胚层）中的任何一种细胞类型，具备自我更新和分化潜能。 iPSC的获得过程通常涉及引入特定的转录因子，以重新激活体细胞中的多能性基因网络。 1.1.1 多能性的分子机制. 多能性是指细胞分 …

2024年4月26日 · In this review, we outline key developments in the iPSC field and highlight the immense versatility of the iPSC technology for in vitro modeling and therapeutic applications. We begin by...

2011年10月4日 · Recent microarray studies have shown that human iPSCs carry elevated levels of DNA copy number variation compared with those in embryonic stem cells, suggesting that these and other classes of genomic structural variation (SV), including inversions, smaller duplications and deletions, complex rearrangements, and retroelement transpositions, may ...

Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell.

2025年1月9日 · In this study, we examined axonal varicosities in human iPSC-derived DA and glutamatergic neurons (i3Neurons). i3Neurons primarily contained small, clear SVs (40–50 nm), whereas DA neurons ...

Induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) are two types of pluripotent stem cells that hold great promise for biomedical research and medical applications. iPSCs were initially favorably compared to ESCs.

诱导性多能干细胞（英語： Induced pluripotent stem cell ），又稱人工誘導多能幹細胞，常簡稱爲iPS細胞（iPSC），是一種由哺乳動物成體細胞經轉入轉錄因子等手段脫分化形成的多能 幹細胞，最早由日本學者山中伸彌的研究團隊於2006年發現 [1] 。

2025年3月13日 · Meanwhile, BMP/FGF/WNT ligands are not increased in sinus venosus (SV) and liver with STM between E9.5 and E10.5 ... IL1α promoted human iPSC-derived liver organoid growth.

Human induced pluripotent stem cells (iPSC) have demonstrated massive potentials for use in regenerative and personalized medicine due to their ability to expand in culture and differentiate into specialized cells with therapeutic benefits.

2024年12月31日 · iPSC全称诱导多功能干细胞（Induced pluripotent stem cells），是一种通过成熟体细胞重新编程获得的多能干细胞，由日本科学家Shinya Yamanaka于2006年建立，并获得2012年的诺贝尔奖。 他们利用4种转录因子（Oct4、Sox2、Klf4和c-Myc）的过表达将小鼠胚胎成纤维细胞诱导成为类似胚胎干细胞（ESC）的状态。 iPSC在形态、基因和蛋白表达、表观遗传修饰状态、细胞倍增能力、类胚体和畸形瘤生成能力、分化能力等方面都与ESC极为相似，具备 …