Isoniazid preventive treatment (IPT) for 6 months was the mainstay of TPT until recently, for both adults and children, HIV-positive and HIV-negative, and in high and low TB incidence countries. Several systematic reviews have consistently demonstrated the efficacy of IPT in preventing TB disease among people infected with M. tuberculosis.

2025年2月22日 · The PHOENIx-MDR TB [NCT03568383] trial aims to compare the safety and efficacy of a six-month regimen of delamanid (DLM) versus a six-month regimen of isoniazid in high-risk household-contacts of adults with MDR-TB over a 96-week follow-up period [20].

TPTs for an infection with M. tuberculosis strains presumed to be drug-susceptible can be broadly categorized into two types: monotherapy with isoniazid for at least 6 months (IPT) and treatment with regimens containing a rifamycin (rifampicin or rifapentine).

TB preventive treatment (TPT) can reduce the risk of individuals developing TB disease and is a powerful and necessary tool to end the global TB epidemic. TPT is, in short, treatment for TB infection through a public health approach, meaning individuals with epidemiologic risk factors for TB infection receive TPT, regardless of

2024年12月28日 · People infected with tuberculosis (TB) are at high risk of progressing to TB disease. Tests can identify people infected with TB who may benefit from preventive treatment. Well-tolerated and effective TB preventive treatment regimens are available and recommended in adults, children, and pregnant people.

2025年2月25日 · Preventing MDR/RR-TB remains a significant challenge towards global TB elimination. While the recent WHO recommendation for 6Lfx is a promising step, expanding TPT options for pre-XDR-TB and addressing drug intolerance are critical. Ongoing as well as new trials are essential to develop alternative treatment and achieve TB elimination.

We find that the optimal epidemiological settings for the programmatic use of IPT against LTBI occur at surprisingly high levels of TB incidence. The NNT initially falls as TB incidence increases, and then follows a U-shaped curve, with the maximal impact of IPT found at a TB incidence of around 720 cases/100 000/year.

TPT for contacts of people with TB strains resistant to both isoniazid and rifampicin (multidrug-resistant TB or MDR-TB) may still be possible but different medicines are used. MDR-TB is a serious form of TB and is less easy to treat than other types of TB disease. Your healthcare worker can help you make the

2024年3月24日 · Multidrug-resistant or rifampicin-resistant TB (MDR/RR-TB; resistance to rifampicin and isoniazid, or rifampicin alone) is a burgeoning public health challenge in several parts of the world, and especially Eastern Europe, Russia, Asia and sub-Saharan Africa.

Isoniazid preventive therapy (IPT) is the provision of the drug isoniazid to people at high risk of developing active tuberculosis (TB). Those with HIV are 20 to 37 times more likely to develop active TB from latent TB than those without HIV, making HIV infection