ERN1 - Wikipedia
The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 α (IRE1α) is an enzyme that in humans is encoded by the ERN1 gene. [5][6] The protein encoded by this gene …
The Structure, Activation and Signaling of IRE1 and Its Role in ...
2021年2月5日 · Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three branches of the Unfolded Protein Response (UPR) signaling pathway, which is …
Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular ...
Inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) is the most prominent and evolutionarily conserved unfolded protein response (UPR) signal transducer during …
IRE1 signaling increases PERK expression during chronic ER stress
2024年4月18日 · Our results demonstrate that the ER stress sensor IRE1 helps to sustain PERK expression during chronic ER stress. This occurs through a mechanism facilitated by IRE1 …
IRE1α is an endogenous substrate of endoplasmic-reticulum ... - PubMed
Here we discover that IRE1α, the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L-Hrd1 ERAD complex. ERAD-mediated IRE1α degradation occurs under …
Frontiers | IRE1α Implications in Endoplasmic Reticulum Stress …
Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most prominent and evolutionarily conserved endoplasmic reticulum (ER) membrane protein. This transduces the …
刘勇课题组揭示未折叠蛋白响应分子IRE1α与应激颗粒共聚集的动 …
2024年5月8日 · 为了深入解析在哺乳动物细胞中IRE1α聚集簇的结构与功能特性，研究人员利用免疫荧光检测、活细胞成像、光遗传学、免疫共沉淀及细胞组分分离等分子与细胞生物学技术手 …
Mammalian IRE1α dynamically and functionally coalesces with …
2024年5月7日 · Here we report that, in mammalian cells, formation of IRE1α clusters is an ER membrane-bound phase separation event that is coupled to the assembly of stress granules …
IRE1α governs cytoskeleton remodelling and cell migration
2018年7月16日 · Here, we identified filamin A as a major binding partner of the ER stress transducer IRE1α. Filamin A is an actin crosslinking factor involved in cytoskeleton …
IRE1α: from the function to the potential therapeutic target in ...
2023年6月13日 · Inositol requiring enzyme 1 (IRE1) is generally thought to control the most conserved pathway in the unfolded protein response (UPR). Two isoforms of IRE1, IRE1α and …