Endoplasmic reticulum stress activates human IRE1α through …
2022年6月22日 · We developed an automated two-color single-molecule tracking approach to dissect the oligomerization of tagged endogenous human IRE1 in live cells. In contrast to …
Endoplasmic reticulum stress activates human IRE1α through
2022年6月22日 · In this study, Belyy et al., have developed a powerful new imaging system--one that will benefit others in the cell biology community--to measure how a key transducer of the …
Dynamics and clustering of IRE1α during ER stress | PNAS
2020年2月4日 · In PNAS, Belyy et al. employ advanced quantitative imaging strategies to reveal the intricacies of the regulation of IRE1 during ER stress in the cellular context. The most …
Vladislav BELYY | PhD candidate | B.S. Molecular ... - ResearchGate
Protein folding homeostasis in the endoplasmic reticulum (ER) is regulated by a signaling network, termed the unfolded protein response (UPR). Inositol-requiring enzyme 1 (IRE1) is an …
Optogenetic platform for dissecting IRE1's enzymatic mechanism
2024年2月8日 · Inositol-requiring enzyme 1 (IRE1) is a bifunctional kinase/RNase that is regulated by oligomeric transitions. When activated, mammalian IRE1 splices a specific mRNA …
2021年9月29日 · We developed an automated two-color single-molecule tracking approach to dissect the oligomerization of tagged endogenous human IRE1 in live cells. In contrast to …
[PDF] Endoplasmic reticulum stress activates human IRE1α through ...
2021年9月30日 · We developed an automated two-color single-molecule tracking approach to dissect the oligomerization of tagged endogenous human IRE1 in live cells. In contrast to …
Dissecting ER stress signaling with live-cell single-molecule …
2024年2月8日 · One of the most conserved ER regulators is inositol-requiring enzyme 1 (IRE1), an ancient ER membrane-resident stress sensor that initiates a potent transcriptional response …
Decoding non-canonical mRNA decay by the endoplasmic …
2021年12月15日 · Inositol requiring enzyme 1 (IRE1) mitigates endoplasmic-reticulum (ER) stress by orchestrating the unfolded-protein response (UPR). IRE1 spans the ER membrane, and …
Quantitative microscopy reveals dynamics and fate of clustered …
2020年1月21日 · The endoplasmic reticulum (ER) membrane-resident stress sensor inositol-requiring enzyme 1 (IRE1) governs the most evolutionarily conserved branch of the unfolded …