IRE1α is an endogenous substrate of endoplasmic-reticulum ... - PubMed
Here we discover that IRE1α, the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L-Hrd1 ERAD complex. ERAD-mediated IRE1α degradation occurs under …
Nat Cell Biol: 内质网相关RNA沉默(ERAS)的发现 - 知乎
ERAD的核心过程由Cdc48/p97/VCP提供能源，Cdc48是一个保守的六聚体II类AAA+ATP酶。除Hrd1外，有许多E3连接酶都显示可以参与介导错误/未折叠蛋白的泛素化，包括AMFR/gp78 …
IRE1α is an endogenous substrate of endoplasmic-reticulum
2015年11月9日 · Here we discover that IRE1α, the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L–Hrd1 ERAD complex. ERAD-mediated IRE1α …
详解内质网应激/未折叠蛋白反应三条信号通路 - 简书
2020年8月8日 · Xbp1s进入细胞核后会启动一系列基因转录(如脂质合成、ERAD等)，从多个层次缓解内质网应激。 除此之外p-IRE1α可以通过RIDD过程促进mRNA的降解，减缓新生多肽链 …
苏州大学特聘教授Nature子刊揭示蛋白降解新机制 - 生物通
Endoplasmic reticulum (ER)-associated degradation (ERAD) represents a principle quality control mechanism to clear misfolded proteins in the ER; however, its physiological significance and …
Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular ...
Inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) is the most prominent and evolutionarily conserved unfolded protein response (UPR) signal transducer during …
Frontiers | IRE1α Implications in Endoplasmic Reticulum Stress …
Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most prominent and evolutionarily conserved endoplasmic reticulum (ER) membrane protein. This transduces the …
Emerging roles for the ER stress sensor IRE1α in metabolic regulation ...
2019年12月6日 · Inositol-requiring enzyme 1 (IRE1) is an endoplasmic reticulum (ER)-resident transmembrane protein that senses ER stress and is evolutionarily conserved from yeast to …
Decoding non-canonical mRNA decay by the endoplasmic …
2021年12月15日 · Inositol requiring enzyme 1 (IRE1) mitigates endoplasmic-reticulum (ER) stress by orchestrating the unfolded-protein response (UPR). IRE1 spans the ER membrane, and …
IRE1: A Role in UPREgulation of ER Degradation - ScienceDirect
2003年2月1日 · Using the secreted, normal α1-antitrypsin (A1AT) or a misfolded variant termed null Hong Kong (NHK), they demonstrate that expression of NHK protein stimulates both …