Genetic interaction and biochemical analyses revealed that Ire1 regulates lipid mobilization by promoting Xbp1s-associated FoxO degradation and suppressing FoxO-dependent lipolytic programs. Our results demonstrate that Ire1 is a catabolic sensor and acts through the Xbp1s-FoxO axis to hamper the lipolytic response during chronic food deprivation.

2022年12月1日 · The results showed that the expression of FoxO1 was significantly promoted following 4μ8C treatment (Fig. 5 C), suggesting that blocking the IRE1 signaling pathway alleviated palmitate-induced FoxO1 expression inhibition. In other words, the IRE1 pathway was involved in palmitate-induced FoxO1 expression.

遗传相互作用和生化分析表明，IRE1通过促进Xbp1s相关的FoxO降解和抑制的FoxO依赖脂肪分解计划调节脂质动员。 我们的研究结果表明，IRE1是分解代谢传感器并通过Xbp1s-的FoxO作用轴线妨碍慢性食物剥夺过程中脂解反应。

2021年8月20日 · Genetic interaction and biochemical analyses revealed that Ire1 regulates lipid mobilization by promoting Xbp1s-associated FoxO degradation and suppressing FoxO-dependent lipolytic programs. Our results demonstrate that Ire1 is a catabolic sensor and acts through the Xbp1s-FoxO axis to hamper the lipolytic response during chronic food deprivation.

2014年11月4日 · Activated FOXO3 bypasses IRE1 requirement for secretory trafficking in human cells • Activated DAF-16 enables autophagy-mediated ERAD alongside proteasome-mediated ERAD • Environmental stresses can activate the DAF-16-mediated ER homeostasis pathway

2014年11月4日 · We show that DAF-16 establishes alternative ER-associated degradation systems that degrade misfolded proteins independently of the ER stress sensor ire-1 and the ER-associated E3 ubiquitin ligase complex sel-11/sel-1.

2021年2月3日 · Genetic interaction and biochemical analyses revealed that Ire1 regulates lipid mobilization through promoting Xbp1s-associated FoxO degradation and suppressing FoxO-dependent lipolytic programs. Our results demonstrate that Ire1 is a catabolic sensor and acts through the Xbp1s-FoxO axis to hamper the lipolytic response during food deprivation.

2021年7月1日 · Our results demonstrate that Ire1 is a catabolic sensor and acts through the Xbp1s-FoxO axis to hamper the lipolytic response during chronic food deprivation. These findings offer new insights...

Forkhead Box O1 (FoxO1) is a transcription factor with a unique fork head domain that indirectly participates in a variety of physiological processes and plays an important role in type 2 diabetes. Palmitate as the most abundant free fatty acid, accounting for …

在所有的生命体中,在应对各种环境压力时,精确维持脂肪的储存和动员的动态平衡对维持能量稳态是非常重要的.未折叠蛋白应答作为一种细胞内关键的调节者,广泛参与到细胞内各种生理过程中来,IRE1α被报道通过调节脂肪代谢相关基因的表达来参与调控脂肪合成,分布以及氧化过程,然而具体的分子机制以及遗传学定义都不是特别清楚.由于果蝇在代谢以及未折叠蛋白应答中的调节作用都是保... 查看全部>> 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技 …