Genetic interaction and biochemical analyses revealed that Ire1 regulates lipid mobilization by promoting Xbp1s-associated FoxO degradation and suppressing FoxO-dependent lipolytic …

2022年12月1日 · The results showed that the expression of FoxO1 was significantly promoted following 4μ8C treatment (Fig. 5 C), suggesting that blocking the IRE1 signaling pathway …

遗传相互作用和生化分析表明，IRE1通过促进Xbp1s相关的FoxO降解和抑制的FoxO依赖脂肪分解计划调节脂质动员。 我们的研究结果表明，IRE1是分解代谢传感器并通过Xbp1s-的FoxO作用 …

2021年8月20日 · Genetic interaction and biochemical analyses revealed that Ire1 regulates lipid mobilization by promoting Xbp1s-associated FoxO degradation and suppressing FoxO …

2014年11月4日 · Activated FOXO3 bypasses IRE1 requirement for secretory trafficking in human cells • Activated DAF-16 enables autophagy-mediated ERAD alongside proteasome-mediated …

2014年11月4日 · We show that DAF-16 establishes alternative ER-associated degradation systems that degrade misfolded proteins independently of the ER stress sensor ire-1 and the …

2021年2月3日 · Genetic interaction and biochemical analyses revealed that Ire1 regulates lipid mobilization through promoting Xbp1s-associated FoxO degradation and suppressing FoxO …

2021年7月1日 · Our results demonstrate that Ire1 is a catabolic sensor and acts through the Xbp1s-FoxO axis to hamper the lipolytic response during chronic food deprivation. These …

Forkhead Box O1 (FoxO1) is a transcription factor with a unique fork head domain that indirectly participates in a variety of physiological processes and plays an important role in type 2 …

在所有的生命体中,在应对各种环境压力时,精确维持脂肪的储存和动员的动态平衡对维持能量稳态是非常重要的.未折叠蛋白应答作为一种细胞内关键的调节者,广泛参与到细胞内各种生理过程 …