Ginsenoside Rb1 reduced ischemic stroke-induced apoptosis …
Longa method, cerebral infarct volume, and HE staining were used to evaluate the efficacy of GRb1 in mice with a mouse model of middle cerebral artery occlusion reperfusion (MCAO/R). …
Pre-ischaemic Treatment with Enriched Environment Alleviates …
2023年3月1日 · In our study, the high expression levels of GRP78, p-PERK, p-IRE1, and ATF6 were observed in cortical tissue of rats in MCAO group, indicating the activation of ER stress …
Mechanisms of intermittent theta-burst stimulation attenuating …
2024年3月1日 · ERS overactivation activates both autophagy and apoptosis, the two pathways of cell death, and triggers cell death. Among them, IRE1 mediates the phosphorylation of the anti …
Mechanism of Endoplasmic Reticulum Stress in Cerebral Ischemia
Endoplasmic reticulum (ER) is the main organelle for protein synthesis, trafficking and maintaining intracellular Ca 2+ homeostasis. The stress response of ER results from the disruption of ER …
Comparison between single and combined post-treatment with S …
2015年8月6日 · To determine whether IRE1 pathway can be affected, we tested the expression of p-IRE1 (activated form of IRE-1) in the penumbra of the infarct of MCAO rats with and without …
Scalp acupuncture alleviates cerebral ischemic stroke-induced …
2023年6月21日 · IRE1 evokes neuronal apoptosis by activating c-Jun NH2-terminal kinase (JNK), while PERK and ATF6 may also trigger cell apoptosis via the C/EBP homologous protein …
Mechanisms of intermittent theta-burst stimulation attenuating …
2024年3月4日 · Protein expression of IRE1, PERK, ATF6, and GRP78 was detected after MCAO/R as well as iTBS intervention. The results showed that MCAO/R rats had higher levels …
Acupuncture protects against cerebral ischemia–reperfusion injury …
2020年11月10日 · Acupuncture treatment decreased infarct volume, neurological score and suppressed ER stress via inactivation of ATF-6, PERK, and IRE1 pathways in MCAO rats. …
XBP1-dependent O-GlcNAcylation is neuroprotective in ischemic …
Here, we report results from an experimental study designed to evaluate the potential of the IRE1/XBP1/HBP/O-GlcNAc axis as a target for neuroprotection in ischemic stroke. Using …
Longxuetongluo Capsule protects against cerebral …
2021年2月9日 · LTC treatment alleviated OGD/R induced ER stress by inhibiting the activation of protein kinase RNA (PKR)-like ER kinase (PERK)/eukaryotic translation initiation factor 2 …