Activation of the IRE1 RNase through remodeling of the kinase …
2020年12月14日 · Inositol-Requiring Enzyme 1 (IRE1) is an essential component of the Unfolded Protein Response. IRE1 spans the endoplasmic reticulum membrane, comprising a sensory lumenal domain, and tandem...
The Structure, Activation and Signaling of IRE1 and Its Role in ...
Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated upon endoplasmic reticulum (ER) stress conditions.
Decoding non-canonical mRNA decay by the endoplasmic …
2021年12月15日 · IRE1 helps mitigate endoplasmic-reticulum stress by cleaving specific mRNAs at a conserved sequence endomotif via regulated IRE1-dependent decay (RIDD).
The Structure, Activation and Signaling of IRE1 and Its Role in ...
2021年2月5日 · Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated upon endoplasmic reticulum (ER) stress conditions. It is known to be capable of inducing both pro-survival and pro-apoptot …
Mammalian IRE1α dynamically and functionally coalesces with …
2024年5月7日 · Here we report that, in mammalian cells, formation of IRE1α clusters is an ER membrane-bound phase separation event that is coupled to the assembly of stress granules (SGs). In response to...
刘勇课题组揭示未折叠蛋白响应分子IRE1α与应激颗粒共聚集的动 …
2024年5月8日，武汉大学生命科学学院刘勇教授课题组在Nature Cell Biology杂志上在线发表了题为“Mammalian IRE1α dynamically and functionally coalesces with stress granules” 的研究论文，发现IRE1α能够在不同应激条件下与应激颗粒（Stress granule,...
Structural and functional basis for RNA cleavage by Ire1
2011年7月6日 · Central to this signaling pathway is the ER-resident bifunctional transmembrane kinase/endoribonuclease Ire1. The endoribonuclease (RNase) domain of Ire1 initiates a non-conventional mRNA splicing reaction, leading to the production of a transcription factor that controls UPR target genes.
Exploring the IRE1 interactome: From canonical signaling …
IRE1 first appeared as a transducer of the UPR, in order to restore a balance in ER homeostasis and help cells adapt to stress. The evolutive interactome unveils possible new roles of IRE1 in mammals. IRE1 is connected with immunity, inflammation, and metabolism and is therefore involved in disease progression (154, 155). While most of the ...
Structure of the Ire1 autophosphorylation complex and …
In the endoplasmic reticulum, unfolded proteins stimulate Ire1 autophosphorylation and RNase activity. The crystal structure of the dephosphorylated kinase/RNase domain of human Ire1 bound to ADP provides insight into the autophosphorylation ...
国际期刊|IF21.3！武汉大学刘勇团队首次揭示内质网应激关键分 …
肌醇需要酶1（IRE1）是位于内质网上的跨膜蛋白，IRE1是从酵母到哺乳动物保存的最古老的内质网应激传感器，具有一个N端内质网管结构域 (LD)，用于检测未折叠/错误折叠的蛋白质负 …