IRE1α RIDD activity induced under ER stress drives neuronal death …
2021年6月3日 · Three ER-resident transmembrane proteins orchestrate the UPR: inositol-requiring enzyme 1 (IRE1), activating transcription factor 6 (ATF6), and protein kinase RNA …
Regulated IRE1α-dependent decay (RIDD)-mediated …
2022年5月6日 · Activated IRE1α cleaves XBP1 mRNA, a key step in production of the transcription factor XBP1s. In addition, IRE1α cleaves select mRNAs through regulated IRE1α …
Getting RIDD of RNA: IRE1 in cell fate regulation - PubMed
For instance, RIDD cleaves RNA at an XBP1-like consensus site but with an activity divergent from XBP1 mRNA splicing and can either preserve ER homeostasis or induce cell death. Here …
PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent ...
2022年10月4日 · PIDDosome ablation or IRE1 inhibition blunt steatohepatitis and diminish INSIG2 expression. Conversely, while inhibiting simple steatosis, SCAP ablation amplifies …
【细胞凋亡原创系列二】细胞凋亡通路 - 知乎 - 知乎专栏
在TNFR-1介导的凋亡通路中，三聚化的TNFR-1募集接头蛋白TRADD，TRADD通过自身的DD可汇聚FADD、RIP和TRAF-2。 这里分2条通路：（1）当结合的是FADD，便导致Caspase-8前体 …
Ire1 Has Distinct Catalytic Mechanisms for - Cell Press
2014年11月6日 · IRE1, an endoplasmic reticulum (ER) kinase/RNase, splices XBP1/HAC1 to produce an active transcription factor but also cleaves ER-associated mRNA through …
IRE1-RIDD调控细胞功能的研究进展 - wanfangdata.com.cn
内质网是细胞内能够精细调控细胞生长、存活及功能的膜系统,是促进细胞内环境稳定的重要细胞器.内质网应激(ERS)中的感应器IRE1具有促细胞存活及促凋亡活性,这主要归因于XBP1 mRNA …
Getting RIDD of RNA: IRE1 in cell fate regulation - ScienceDirect
2014年5月1日 · Inositol-requiring enzyme 1 (IRE1) is the most conserved transducer of the unfolded protein response (UPR), a homeostatic response that preserves proteostasis. …
Regulated IRE1α-dependent decay (RIDD)-mediated …
2022年5月6日 · Activated IRE1α cleaves XBP1 mRNA, a key step in production of the transcription factor XBP1s. In addition, IRE1α cleaves select mRNAs through regulated IRE1α …
In this study, we employed unbiased lipidomic and tran-scriptomic approaches to investigate the contribution of IRE1 α signaling to lipid metabolism in TNBC. The integration of these data …