Divergence and Conservation of the Major UPR Branch IRE1-
2016年6月3日 · The inositol requiring enzyme 1 (IRE1) signaling pathway activated by the IRE1-mediated unconventional splicing of HAC1 in yeast, bZIP60 in plants and XBP1 in metazoans, …
IRE1 | SGD - Saccharomyces Genome Database
2000年4月7日 · IRE1 encodes a transmembrane protein that is involved in the unfolded protein response (7, 8, 9).
ER stress signaling by regulated splicing: IRE1/HAC1/XBP1
2005年4月1日 · Here, we summarize various approaches to study the IRE1–Hac1 pathway in yeast and the homologous IRE1–XBP1 pathway in mammalian cells. We present …
Specificity in endoplasmic reticulum-stress signaling in yeast
2014年12月30日 · In eukaryotic cells including yeast, a sensor protein called Ire1 detects when unfolded proteins build up in the endoplasmic reticulum. As a result, the Ire1 sensor proteins …
Regulation of the unfolded protein response in yeast by oxidative ...
In the unfolded protein response (UPR), Ire1 activates Hac1 to coordinate the transcription of hundreds of genes to mitigate ER stress. Recent work in Caenorhabditis elegans suggests …
Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular ...
Inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) is the most prominent and evolutionarily conserved unfolded protein response (UPR) signal transducer during …
Regulation of the Unfolded Protein Response in Yeast by …
In the unfolded protein response (UPR), Ire1 activates Hac1 to coordinate the transcription of hundreds of genes to mitigate ER stress. Recent work in C. elegans suggests that oxidative …
The UPR Branch IRE1-bZIP60 in Plants Plays an Essential Role in
2015年4月15日 · As the major sensor of UPR in eukaryotes, IRE1, in response to endoplasmic reticulum (ER) stress, catalyzes the unconventional splicing of HAC1 in yeast, bZIP60 in …
IRE1: Developmental Cell - Cell Press
The unfolded protein response entered the mechanistic realm with the discovery of IRE1 as the key signal transducer in yeast. Although also found in mammals, it appeared to function in …
Crucial roles of Grr1 in splicing and translation of - Nature
2025年3月4日 · In the UPR signaling pathway, HAC1 mRNA in budding yeast 32,33,34 or XBP1 mRNA in metazoans 32,33,34 is targeted to the ER-resident protein kinase and endonuclease …