IRF3 inhibits inflammatory signaling pathways in macrophages
2024年8月9日 · Here, we used conditional Irf3 knockout (Irf3 Δ/Δ) and macrophage-specific Irf3 knockout (Irf3 MKO) mice to evaluate the role of IRF3 in preventing viral inflammation and …
IRF3 regulates neuroinflammatory responses and the expression …
2024年8月30日 · Here, we show that global IRF3 deficiency delays TLR4-mediated signaling in microglia and attenuates the hallmark features of LPS-induced inflammation such as cytokine …
DNA-PK inhibition sustains the antitumor innate immune response …
As shown in Figures S3C and S3D, DNA-PKi induced a significant increase in p-IRF3 MFI (p < 0.05) and significantly promoted p-IRF3 translocation to the nuclear compartment (p < 0.005), …
Antiviral innate immune memory in alveolar macrophages …
2024年9月30日 · We exposed alveolar macrophages to polyIC for 24 h, washed, and restimulated with polyIC after 5 days. Alveolar macrophages that previously experienced polyIC showed …
An integrin axis induces IFN-β production in plasmacytoid …
We find that this sOpn/IFN-β axis is MyD88 independent but operates via phosphoinositide 3-kinase (PI3K)/mammalian target for rapamycin (mTOR)/IFN regulatory factor (IRF)3 activation. …
Human OTUD6B positively regulates type I IFN antiviral innate
2023年8月31日 · Confocal microscopy showed that more IRF3 translocated to the nucleus with overexpressing OTUD6B upon viral infection as measured using mean fluorescence intensity …
Interferon response and epigenetic modulation by - Science
2024年12月4日 · We proceeded to evaluate whether activation of ISGs is dependent on the IRF3, a key upstream regulator of type I IFN gene transcription. Loss of SMARCA4 was associated …
cGAS-STING 信号通路发现史（上） - 知乎专栏
IRF3 结构示意图：DNA 结合结构域(DNA binding domain，DBD)，干扰素调节因子结合结构域(IRF association domain，IAD)，调节结构域(regulatory domain, RD)，核定位序列(the nuclear …
Activated PI3K/Akt/mTOR increases IRF3 activity by upregulated...
Posttranslational activation of mTOR signaling pathway and phosphorylation of p70S6 kinase lead to enhanced Irf3 mRNA transcription. IRF3 protein is phosphorylated and translocated to the...
IRF3 inhibits inflammatory signaling pathways in macrophages to …
Here, we used conditional Irf3 knockout (Irf3 Δ/Δ) and macrophage-specific Irf3 knockout (Irf3 MKO) mice to evaluate the role of IRF3 in preventing viral inflammation and pathogenesis. Irf3 …