Additionally, seven highly populated biological pathways with the IRDS genes were identified, and with recording their frequently associated genes (IFIT1/3, IFITM1, IRF7, ISG15, MX1/2 and OAS1/3/L). To capture novel insights within IRDS genes we further investigated their tertiary structures, with providing a glance of functional interfaces.

2018年5月16日 · In this Review, we describe new insights into how ISG15 directly inhibits viral replication and discuss the recent finding that ISG15 modulates the host damage and repair response, immune...

Interferon-stimulated gene 15 (ISG15) plays an important antiviral role during viral infection. ISG15 catalyzes a ubiquitin-like post-translational modification termed ISGylation, involving the conjugation of ISG15 molecules to de novo synthesized viral or cellular proteins, which regulates their stability and function. Numerous biomedically ...

2021年10月20日 · In this issue of Nature Immunology, Sanyal and colleagues show that SARS-CoV-2 infection of human macrophages induces the release of intracellular ISG15 (interferon-stimulated gene 15, one of the...

2019年3月12日 · Several ISGs, including IFIT1, IFIT2, IFIT3, Mx1, Mx2, CXCL10 and ISG15 were found to be upregulated transcriptionally following HCMV infection independently of type I IFN-initiated JAK-STAT signaling, but dependent on intact IRF3 signaling.

The ubiquitin-like protein ISG15 is one of the most significantly up-regulated host factors in HIV-infected patients, inhibiting the budding and release of HIV...

2015年8月11日 · Listeria-mediated ISG15 induction depends on the CSP, which senses bacterial DNA and signals through STING, TBK1, IRF3, and IRF7. Most importantly, we demonstrate that ISG15 counteracts Listeria infection both in vitro and in vivo.

2023年12月1日 · ISG15 in its unconjugated (free) form fine-tunes intracellular signaling cascades and, upon extracellular secretion, functions ‘cytokine-like’, contributing to immunomodulation. Viruses from diverse families have evolved tactical strategies to manipulate ISG15-mediated antiviral responses.

2023年5月5日 · Interferon stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that is highly induced upon activation of interferon signaling and cytoplasmic DNA sensing pathways. As part of the innate immune system ISG15 acts to inhibit viral replication and particle release via the covalent conjugation to both viral and host proteins.

2018年2月1日 · Interferon (IFN)-stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that is heavily involved in immune response elicitation. As an important member of interferon regulatory factor (IRF) family, IRF1 can activate the expression of multiple genes, including the human optineurin gene (Sudhakar et al., 2013).