2012年12月14日 · IFN-induced protein with tetratricopeptide repeats (IFIT) proteins — which are induced after type I interferon (IFN)- or IFN-regulatory factor 3 (IRF3)-dependent signalling — contribute to...

摘要: IFIT1是一种高度诱导的具有四肽重复序列的干扰素刺激基因家族 (ISGs)成员，主要存在于细胞质，其表达受干扰素 (IFN)、多种病毒和某些病原体相关分子模式的调节，具有抗病毒、抗炎等作用。 IFIT1的抗病毒作用可通过多种机制和途径发挥，同时部分病毒也进化出独特的机制逃避宿主IFIT1的限制作用，从而对抗机体抗病毒免疫。 在许多炎症性疾病中，IFIT1也显示出其独特的抗炎作用。 该文就IFIT1的抗炎和抗病毒作用与相关机制作一综述，为进一步研究相关疾病的治 …

Activated IRF3 can induce ISGs directly, in the absence of IFN production, or co-operate with additional transcription factors such as IRF1, IRF7 and NF- κ B to elicit type 1 IFN production.

IRF1, IRF3 and IRF7 are capable of inducing ISGs in an IFN-independent manner as reported for the STAT independent expression of ISGs including beta 2- microglobulin (β2m), guanylate binding protein (GBP), Myxovirus protein A (MxA), CXCL10, ISG15 and MHC-I …

In addition to IRF9, other IRF transcription factor family members (e.g., IRF1, IRF3, and IRF7) induce IFITM expression independent of the STAT pathway (53, 54). Moreover, in addition to IFNs, IFITM expression is stimulated by other inflammatory cytokines (IL-6 and oncostatin M) and angiotensin II, a hormone that increases blood pressure by ...

该基因编码一种含有四肽重复序列的蛋白质，最初被鉴定为在干扰素处理后被诱导产生。 编码的蛋白质可以抑制病毒复制和翻译起始。 该基因与其他五个密切相关的基因位于 10 号染色体上的一个簇中。 该基因在 13 号染色体上有一个假基因。 已经观察到编码多种亚型的可变剪接转录物变体。 [RefSeq 提供，2012 年 8 月] This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon.

2014年10月1日 · IFIT1 can detect viral RNA lacking 2 ′ -O methylation on their cap structures or displaying a 5′-triphosphate moiety and inhibit their translation or sequester them from active replication.

IFIT1 binds tightly to non-self RNA, particularly capped transcripts lacking methylation on the first cap-proximal nucleotide, and inhibits their translation by out-competing the cellular...

IFN-induced protein with tetratricopeptide repeats (IFIT) proteins — which are induced after type I interferon (IFN)- or IFN-regulatory factor 3 (IRF3)-dependent signalling — contribute to antiviral defence against some viruses by binding to ...

Adapter proteins MYD88, TRIF and ISP-1 are used by the receptor complex that activate IRF3 and IRF7 by phosphorylaton, which then bind the DNA to stimulate IFN expression. Secreted IFN binds the receptor IFNAR at the cell surface, followed by activation of STAT1 and STAT2.