2016年1月25日 · Our findings demonstrate that IRF7 regulates the expression of genes involved in antiviral immunity, inflammation, and the response to oxidative stress during HRV infections …

In vivo infection studies were performed by injecting mice with anti-CCL7 antibody/isotype control, IRF7-siRNA/control siRNA. IRF7 promoted IFN-α and IFN-β production, as well as neutrophil …

We identify the transcription factor interferon regulatory factor 7 (IRF-7), a heterodimer partner of IRF-3, as a target for non–antibiotics-based therapy of bacterial infections. We found that the …

2011年4月14日 · Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial...

At the Irf7 promoter, SRSF7 maximizes STAT1 transcription factor binding and RNA polymerase II elongation via cooperation with the H4K20me1 histone methyltransferase KMT5a (SET8). …

In lung epithelial cells, type I and III IFN induction by IAV is dependent on RIG-I and TLR3 activation. To examine the role of IRF7 induction in this process, we first examined the effect …

We demonstrate that transcriptional repression of IRF7 by MYC provides an additional layer of tight regulation of IRF7 that ensures the appropriate level of type I IFN production and …

2025年2月8日 · SiRNA-mediated inhibition of IRF7 reduces HIV-1 Tat-induced modulation of interferon (IFN)-stimulated genes in immature dendritic cells and in monocyte-derived …

IRF7 Human Pre-designed siRNA Set A contains three designed siRNAs for IRF7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control. …

2016年7月14日 · We show that lipid-based reagent DOTAP was extremely efficient for siRNA delivery into pDC and did not induce cell death or pDC activation. We successfully silenced …