
Interferon regulatory factor 7 regulates airway epithelial cell ...
2016年1月25日 · Our findings demonstrate that IRF7 regulates the expression of genes involved in antiviral immunity, inflammation, and the response to oxidative stress during HRV infections …
Interferon regulatory factor 7 in inflammation, cancer and infection
In vivo infection studies were performed by injecting mice with anti-CCL7 antibody/isotype control, IRF7-siRNA/control siRNA. IRF7 promoted IFN-α and IFN-β production, as well as neutrophil …
IRF7 inhibition prevents destructive innate immunity—A
We identify the transcription factor interferon regulatory factor 7 (IRF-7), a heterodimer partner of IRF-3, as a target for non–antibiotics-based therapy of bacterial infections. We found that the …
IRF7: activation, regulation, modification and function
2011年4月14日 · Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial...
Serine/arginine-rich splicing factor 7 promotes the type I …
At the Irf7 promoter, SRSF7 maximizes STAT1 transcription factor binding and RNA polymerase II elongation via cooperation with the H4K20me1 histone methyltransferase KMT5a (SET8). …
IRF7 Is Required for the Second Phase Interferon Induction during ...
In lung epithelial cells, type I and III IFN induction by IAV is dependent on RIG-I and TLR3 activation. To examine the role of IRF7 induction in this process, we first examined the effect …
Transcriptional repression of IRF7 by MYC is critical for type I ...
We demonstrate that transcriptional repression of IRF7 by MYC provides an additional layer of tight regulation of IRF7 that ensures the appropriate level of type I IFN production and …
IRF7 interferon regulatory factor 7 [ Homo sapiens (human) ]
2025年2月8日 · SiRNA-mediated inhibition of IRF7 reduces HIV-1 Tat-induced modulation of interferon (IFN)-stimulated genes in immature dendritic cells and in monocyte-derived …
IRF7 Human Pre-designed siRNA Set A | siRNA | MCE - MCE-生物 …
IRF7 Human Pre-designed siRNA Set A contains three designed siRNAs for IRF7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control. …
An efficient method for gene silencing in human primary …
2016年7月14日 · We show that lipid-based reagent DOTAP was extremely efficient for siRNA delivery into pDC and did not induce cell death or pDC activation. We successfully silenced …
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