ACO1, or IRP1, is a bifunctional protein that functions as an iron-responsive element (IRE)-binding protein involved in the control of iron metabolism by binding mRNA to repress …

Iron regulatory protein 1 (IRP1/ACO1) is a bifunctional protein present in the cytoplasm that re-sponds to cytosolic iron status mainly through an iron-sulfur switching mechanism, alternating …

IRP1是一种双功能酶，在细胞内铁富足的情况下，IRP1获得铁硫簇，发挥乌头酸酶活性，参与线粒体呼吸。 而当细胞内铁不足时，IRP1失去铁硫簇，与IRE结合，参与细胞内铁稳态的调节。 …

2006年7月18日 · Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register cytosolic iron concentrations and post-transcriptionally regulate expression of iron...

Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) …

铁调节蛋白1 (IRP1/ACO1) 是存在于细胞质中的双功能蛋白质,主要通过铁–硫开关机制来反应细胞溶质铁状态,在具有连接到其活性位点的铁–硫簇的活性细胞溶质乌头酸酶形式和结合铁反应元 …

2011年11月24日 · Iron regulatory proteins (IRPs) 1 and 2 are RNA-binding proteins that control cellular iron metabolism by binding to conserved RNA motifs called iron-responsive elements …

2019年11月29日 · Iron Regulatory Protein 1 (IRP1) is a bifunctional cytosolic iron sensor. When iron levels are normal, IRP1 harbours an iron-sulphur cluster (holo-IRP1), an enzyme with...

2022年9月15日 · Iron regulatory protein 1 (IRP1) is a bifunctional protein with mutually exclusive RNA-binding or enzymatic activities that depend on the presence of a 4Fe-4S cluster. While …

IRP1 can assume two different functions in the cell, depending on conditions. During iron scarcity or oxidative stress, IRP1 binds to mRNA stem-loop structures called iron responsive elements …