Insulin receptor substrate 1 plays a key role in transmitting signals from the insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF-1) to intracellular pathways PI3K / Akt and Erk MAP kinase pathways.

胰岛素受体底物 (insulin receptor substrate，IRSs)是一种能够被激活的胰岛受体酪氨酸激酶的底物, 其上具有十几个酪氨酸残基可被磷酸化，磷 酸化的IRSs能够结合并激活下游效应物。

胰岛素受体底物(insulin receptor substrate，IRS) 是指能够被激活的胰岛素受体酪氨酸激酶作用的底物， 其上具有十几个酪氨酸残基，可被磷酸化，磷酸化的IRS能够结合并激活下游效应物。

2024年12月25日 · IRS1 (Insulin Receptor Substrate 1) is a Protein Coding gene. Diseases associated with IRS1 include Type 2 Diabetes Mellitus and Three M Syndrome 1. Among its related pathways are IL-9 Signaling Pathways and Insulin receptor signalling cascade.

2003年12月1日 · Insulin receptor substrate-1 (IRS1) is a substrate of the insulin receptor tyrosine kinase and appears to have a central role in the insulin-stimulated signal transduction pathway. Therefore, the IRS1 gene has been studied extensively as a candidate gene for type 2 diabetes.

支架蛋白胰岛素受体底物1（irs-1）是胰岛素/igf信号传导中的一个重要节点。人们早就认识到，irs-1的稳定性取决于其内膜靶向性。然而，irs-1如何靶向细胞内膜，以及实际靶向的细胞内膜类型，仍知之甚少。 2023年8月…

2022年6月28日 · As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. A long and unstructured C-terminal region of IRS-1 recruits...

IRS-1 is a principal substrate of the insulin receptor tyrosine kinase. It undergoes multi-site tyrosine phosphorylation and mediates the insulin signal by associating with various signaling molecules containing Src homology 2 domains. Interleukin-4 also stimulates IRS-1 phosphorylation, and it is s …

2022年6月28日 · As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. A long and unstructured C-terminal region of IRS-1 recruits downstream effectors for promoting insulin/IGF signals.

2005年1月1日 · IRS1 belongs to the IRS family of adaptor molecules and is tyrosine phosphorylated in response to insulin, insulin growth factor-1 and cytokines. IRS1 plays a critical role in insulin signaling. IRS1 contains Pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains at the N-terminus which couple IRS1 to phosphorylated IR.