2020年8月3日 · This editorial is intended to introduce the rationale that has led to the establishment of the Clearance of Interstitial Fluid (ISF) and CSF (CLIC) group, within the Vascular Professional Interest Area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment.

为了进一步探究动物实验中产生的分歧结果，2020年发表于Nature Communications的一项研究以CSF示踪动物实验为基础，探究了人类中的CSF回流途径，利用磁共振成像（MRI）和脑脊液示踪剂（CSF tracer），首次展现了CSF可直接外流到矢状窦旁硬脑膜（parasagittal dura, PSD）。

2018年9月4日 · 因此，来自大脑主体（薄壁组织）的蛋白质和废物沿着血管壁在ISF内运输，到达脑脊液（CSF），脑脊液循环通过脑膜。 有研究表明，蛋白质、代谢废物和其它分子在这些流体可以通过血管壁的运输从大脑中清除，从而通过 血脑屏障，这一过程被称为跨血管清除。 但尚不清楚脑膜淋巴管是否与清除废物有关。 Da Mesquita 等人通过将一种具有血管损伤的药物注射到小脑延髓池（脑膜腔内充满脑脊液的大空间），来破坏小鼠的脑膜淋巴管。 然后，他们将荧光示 …

2020年8月3日 · Our interdisciplinary group aims to further the understanding of how ISF and CSF are involved in the pathology of AD and related dementias and how ISF and CSF may be harnessed for diagnostic tests and for disease-modifying therapies.

Brain interstitial fluid (ISF) is contiguous with cerebrospinal fluid (CSF) and exchanges freely with brain tissue across the ependymal and cortical surfaces that have gap junctions rather than tight junctions.

2020年2月1日 · The brain interstitial fluid (ISF) and the cerebrospinal fluid (CSF) cushion and support the brain cells. The ISF occupies the brain interstitial system (ISS), whereas the CSF fills the brain ventricles and the subarachnoid space. The brain ISS is an asymmetrical, tortuous, and exceptionally confine …

Excluding the vasculature, there are four major brain fluid compartments: CSF within the ventricular system, CSF around the brain in the subarachnoid space (which also communicates with the perivascular space of penetrating arteries and arterioles, as well as venules (Abbott et al., 2018)), ISF within the brain extracellular space (ECS), and ...

2023年10月28日 · The overarching objectives of the CLIC group are to: (1) understand the age-related physiology changes that underlie impaired clearance of interstitial fluid (ISF) and cerebrospinal fluid (CSF) (CLIC); (2) understand the cellular and molecular mechanisms underlying intramural periarterial drainage (IPAD) in the brain; (3) establish novel ...

2021年10月19日 · Intracranial extracellular fluid exists in the form of plasma, ISF, or CSF. Composition of plasma varies significantly compared with ISF and CSF, containing approximately 270 times more protein, twice the amount of sugar, and three times that of amino acids (5).

2016年3月1日 · Recent studies describing the glymphatic pathway for the perivascular exchange of CSF and ISF, suggest that CSF circulation, and glial and vascular function are intimately associated and together facilitate the appropriate clearance …