ISG15-deficiency is a very rare genetic disorder caused by mutations of the ISG15 gene. It is inherited with an autosomal recessive pattern and is classified as a primary immunodeficiency or inborn error of immunity. Patients present in childhood with infectious, neurologic or …

2024年12月25日 · ISG15 (ISG15 Ubiquitin Like Modifier) is a Protein Coding gene. Diseases associated with ISG15 include Immunodeficiency 38 With Basal Ganglia Calcification and Influenza. Among its related pathways are SARS-CoV-2 Infection and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template.

2018年5月16日 · In this Review, we describe new insights into how ISG15 directly inhibits viral replication and discuss the recent finding that ISG15 modulates the host damage and repair response, immune...

干扰素刺激基因(interferon-stimulated genes,ISGs)是一类快速的干扰素刺激反应基因,主要参与抵抗病毒,细菌入侵及免疫功能调节.干扰素刺激基因15(interferon-stimulated gene 15,ISG15)是ISGs家族成员之一,也是第一个被鉴定出来的泛素样蛋白(ubiquitin-like protein,UBL),它既可以以游 …

2022年11月1日 · ISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like protein (UBL), which plays multifaceted roles not only as a free intracellular or extracellular...

isg15 泛素样修饰因子： 由该基因编码的蛋白质是一种泛素样蛋白质，在被干扰素-α 和干扰素-β 激活后与细胞内靶蛋白结合。 编码的蛋白质具有多种功能，包括对嗜中性粒细胞的趋化活性、将目标蛋白连接到中间丝的方向、细胞间信号传导以及病毒感染期间的抗 ...

2022年2月4日 · One of the earliest ISGs induced by IFNs is ISG15 (Interferon-Stimulated Gene 15). Free ISG15 protein synthesized from the ISG15 gene is post-translationally conjugated to cellular proteins and is also secreted by cells into the extracellular milieu. ISG15 comprises two ubiquitin-like domains (UBL1 and UBL2), each of which bears a striking ...

2023年12月1日 · ISG15 in its unconjugated (free) form fine-tunes intracellular signaling cascades and, upon extracellular secretion, functions ‘cytokine-like’, contributing to immunomodulation. Viruses from diverse families have evolved tactical strategies to manipulate ISG15-mediated antiviral responses.

2014年10月12日 · Intracellular ISG15 is an interferon (IFN)-α/β-inducible ubiquitin-like modifier which can covalently bind other proteins in a process called ISGylation; it is an effector of...

2023年5月5日 · Interferon stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that is highly induced upon activation of interferon signaling and cytoplasmic DNA sensing pathways. As part of the innate immune system ISG15 acts to inhibit viral replication and particle release via the covalent conjugation to both viral and host proteins.