Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. [5] This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors .

2024年12月25日 · ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. Diseases associated with ITGB1 include Gallbladder Cancer and Breast Cancer. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Integrin Pathway.

Integrin beta-1 (ITGB1)靶点介绍及实验小贴士靶点介绍助您了解其蛋白功能，蛋白表达，蛋白定位及异构体和翻译后修饰等特质。 同时列举了实用的WB实验小贴士，助您实验成功。

2024年1月26日 · This review summarizes the biological roles of ITGB1 in benign diseases and cancers, and compiles the current status of ITGB1 function and therapy in various aspects of tumorigenesis and progression. Finally, future research directions and application prospects of ITGB1 are suggested.

Integrin是由α（120~185kD）和β（90~110kD）两个亚单位形成的异二聚体跨膜糖蛋白，迄今已发现约18种α亚单位和8种β亚单位，它们按不同的组合构成20余种功能不同的Integrin分子。 Integrin在正常组织或细胞中可以介导细胞与细胞外基质（ECM）以及细胞与细胞之间的粘附。

Data suggest that ITGB1 is critical ligand to enhance cell-extracellular matrix contact force and thus promotes cell proliferation; ITGB1 knockdown affects leiomyomal cell spreading but not adhesion; ITGB1 may function in progression of leiomyoma.

2021年12月17日 · Integrin β1 (ITGB1), which acts as an extracellular matrix (ECM) receptor, has gained increasing attention as a therapeutic target for the treatment of hepatocellular carcinoma (HCC). However, the underpinning mechanism of how ITGB1 drives HCC progression remains elusive. In this study, we first fou …

2024年1月26日 · 整合素 β-1 （ITGB1） 是跨膜糖蛋白信号转导受体家族的重要成员，也是整合素家族的核心成员。 它与其他配体形成异二聚体，参与细胞内信号传导并控制多种细胞过程，例如血管生成和神经元的生长;由于其在膜内外的双向信号调节中的作用，ITGB1 必须与多种物质相互作用，因此各种干扰因素会影响 ITGB1 并导致其功能发生变化。 在过去的 20 年里，许多研究证实了 ITGB1 失调与多种良性疾病和实体瘤类型的癌症发生进展之间存在明确的因果关系，这可能意 …

整合素家族成员是参与细胞粘附和识别的膜受体，参与多种过程，包括胚胎发生、止血、组织修复、免疫反应和肿瘤细胞的转移扩散。 该基因编码一个β亚基。 已针对该基因发现了编码不同蛋白质亚型的多个选择性剪接转录物变体。 [RefSeq 提供，2008 年 7 月] Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals.

2025年2月8日 · A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of integrin, beta 1 (ITGB1, fibronectin receptor, CD29) expression by HIV-1 Vpr in Vpr transduced macrophages