2024年12月25日 · ITGB3 (Integrin Subunit Beta 3) is a Protein Coding gene. Diseases associated with ITGB3 include Bleeding Disorder, Platelet-Type, 24 and Glanzmann Thrombasthenia 2. Among its related pathways are Signaling downstream of RAS mutants and Apoptotic Pathways in Synovial Fibroblasts.

Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. [5] CD61 is a cluster of differentiation found on thrombocytes. [6]

The ITGB3 gene provides instructions for making the beta3 subunit of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3), which is found on the surface of small cells called platelets. Learn about this gene and related health conditions.

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins.

β3 integrin (ITGB3), also known as CD61 or GP3A, is one of the most widely studied components in the integrin family. As an adhesion receptor on the cell surface, ITGB3 participates in reprogramming tumor metabolism, shaping the stromal and immune ...

2011年12月1日 · Transmitted by autosomal recessive inheritance, platelets in GT have quantitative or qualitative deficiencies of the fibrinogen receptor, αIIbβ3, an integrin coded by the ITGA2B and ITGB3 genes.

ITGB3 (integrin beta 3 or beta3) is regulated by the Polycomb protein CBX7. Integrin-beta3 is the major driver for fibronectin assembly in cancer-associated fibroblasts, as its inhibition abrogates CAF mediated cancer cell invasion.

2007年2月6日 · Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands.

A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIb/beta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia.

2012年8月27日 · The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins.