ITK (IL-2-inducible tyrosine kinase) belongs to the Tec family kinases and is mainly expressed in T cells. It is involved in TCR signalling events driving processes like T cell development as well …

2020年8月18日 · Interleukin-2-inducible T cell kinase plays a central role in the signal transduction of the T cell receptor. By binding of the MHC to the TCR, the kinase Lck (lymphocyte-specific …

2024年11月26日 · IL-2-inducible T cell kinase (ITK) is a critical modulator of the strength of T cell receptor signaling, while its role in CAR signaling is unknown. By electroporation of CRISPR …

该基因编码在 T 细胞中表达的细胞内酪氨酸激酶。 该蛋白质包含 SH2 和 SH3 结构域，这两个结构域通常存在于细胞内激酶中。 它被认为在 T 细胞增殖和分化中发挥作用。 [RefSeq 提 …

2020年8月18日 · ITK (IL-2-inducible tyrosine kinase) belongs to the Tec family kinases and is mainly expressed in T cells. It is involved in TCR signalling events driving processes like T cell …

IL2-inducible T cell kinase (Itk) is part of the Tec family of tyrosine kinases and is a critical component of T cell receptor mediated signaling. Here, we showed that either genetic ablation …

Itk (Interleukin-2-inducible T-cell kinase) is a Tec family tyrosine kinase that mediates signaling processes after T cell receptor engagement. Activation of Itk requires recruitment to the …

2024年12月2日 · 该研究发现，IL-2诱导T细胞激酶（ITK）可以作为基因敲除或抑制的靶点，通过敲除或抑制ITK，促进CAR-T细胞的体内存活，从而更有效地控制肿瘤复发。 此项研究为开发 …

ITK is a key signaling mediator downstream of TcR, mediating T cell positive selection, innate T cell and CD4 + Th2/Th17 differentiation. Here we show that ITK also negatively tunes IL-2 …

2021年8月20日 · IL-2-inducible T cell kinase (ITK) is essential for proximal T cell receptor (TCR) signaling. Following TCR ligation, ITK is recruited to the cell membrane where it interacts with …