Tyrosine-protein kinase ITK/TSK also known as interleukin-2-inducible T-cell kinase or simply ITK, is a protein that in humans is encoded by the ITK gene. [5] ITK is a member of the TEC family of kinases and is highly expressed in T cells .

Know comprehensive ITK protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation 1, 2, 3 .

ITK deficiency is a genetic cause of idiopathic CD4+ T-cell lymphopenia. Data indicate reduced T-cell activation by altered IL-2 inducible T-cell kinase (ITK) expression in vitro. T-cell-specific human ITK-Syk oncogene in mice leads to early polyclonal …

2020年8月18日 · Interleukin-2-inducible T cell kinase plays a central role in the signal transduction of the T cell receptor. By binding of the MHC to the TCR, the kinase Lck (lymphocyte-specific protein tyrosine kinase) becomes activated with the help of Zn 2+.

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

The N-terminal PH domain allows ITK to be recruited to the plasma membrane by an activated PI3 kinase. This domain contains also a proline-rich region (PRR). The adjoining domain is a SH3 domain, which binds to PRR (from itself or from other proteins).

These investigations show that ITK-SYK fusion protein tend to associate with lipid rafts and are capable of phosphorylating and activating TCR proximal intracellular signaling proteins (like SLP-76) in an antigen-independent manner.

Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells.

In T cells, the predominant Tec kinase is Itk, which functions downstream of the T-cell receptor to regulate phospholipase C-gamma. This review highlights recent advances in our understanding of Itk kinase structure and enzymatic regulation, focusing on Itk protein domain interactions and mechanisms of substrate recognition.