Non-IV BDZ, compared to IV BDZ, terminate seizures faster and have a superior efficacy and side effect profile. Higher-quality studies and further evaluation in different age groups are warranted.

Remimazolam (CNS7056) is a new ultra-short-acting intravenous (IV) BDZ developed by the pharmaceutical company PAION AG and acts on γ-aminobutyric acid type A (GABA A) receptors. 10 Owing to its “soft drug” (self-metabolising and organ-independent) design, it is rapidly hydrolyzed in the body as an inactive carboxylic acid (CNS7054) by tissue es...

2017年3月25日 · Non-IV BDZ, compared to IV BDZ, terminate seizures faster and have a superior efficacy and side effect profile. Higher-quality studies and further evaluation in different age groups are warranted.

compared the IV administration of a BDZ (of any kind) as treatment for status epilepticus with that of a rectal, buccal, intranasal (IN), or intramuscular (IM; non-IV) BDZ of any kind. We included studies on both pediatric and adult populations in our analysis. In addition, we did not restrict our review to the English language.

This study demonstrates that a clinical and, to a lesser degree, EEG response to an acute trial of IV BDZs are predictive of subsequent outcome in patients with suspected NCSE, and warrant further consideration and investigation for assessing and managing patients.

2021年12月1日 · To assess the efficacy, safety, and acceptability of intranasal midazolam in children with acute seizure when compared to conventional IV or rectal benzodiazepine (BDZ). PubMed, google scholar, websites clinicaltrials.gov and the WHO-international clinical trials registry platform, were searched.

2017年9月15日 · BZDs are first-line agents for termination of seizures in status epilepticus. If IV access is available, lorazepam 4 mg IV (0.1 mg/kg IV, in children, max 4 mg) should be administered, and repeated in 5 minutes as needed. Onset of action is within 2 minutes, and duration is 4-6 hours.

Five clinically available 1,4-benzodiazepines (BDZs) (chlordiazepoxide, diazepam, oxazepam, nitrazepam, and clonazepam) and four investigational 1,4-BDZs (BDZ I, BDZ II, BDZ III, and BDZ IV) were tested in vivo for minimal neurotoxicity (TD50) and for ability to obtund seizures (ED50) induced by a b …

2015年5月31日 · BZD作用於中樞神經系統 GABA-A受體上的 benzodiazepine receptor，增加神經元細胞膜氯離子的通透性，造成超極化的不反應狀態，達到神經抑制的作用。 表格中把院內有的口服 BZD品項從較短效的 Brotizolam (短效多記一個院內只有針劑的 Midazolam)，到中效的 Lorazepam, Alprazolam至長效的 Fludiazepam, Diazepam由上到下排列，適應症大同小異，幾乎都是焦慮或失眠，除了 Clonazepam為癲癇治療用。 起始作用時間約半小時。

Intubation/ventilation for coma, BDZ for seizures, NaHCO3 for ↑QRS, K for hypokalemia, high dose diazepam IV infusion considered. Delayed absorption of SR may cause days of CNS/AC symptoms. Levels in therapeutic range for 48-72hrs may need to be observed after significant OD.