The type IV pilin is a remarkably versatile architectural module that has been adopted widely for a variety of functions, including motility, attachment to chemically diverse surfaces, electrical conductance, acquisition of DNA, and secretion of a broad range of …

Pilin protein from Neisseria gonorrhoeae, a parasitic bacterium that requires functional pili for pathogenesis. Type IV pilin proteins are α+β proteins characterized by a very long N-terminal alpha helix. The assembly of these pili relies on interactions between the N-terminal helices of the individual monomers.

2019年4月15日 · Type IV pilus (T4P) retraction enables motility and taxis, surface sensing, self-organization of microcolonies and DNA uptake.

Type IV pili are versatile and highly flexible fibers formed on the surface of many Gram-negative and Gram-positive bacteria. Virulence and infection rate of several pathogenic bacteria, such as Neisseria meningitidis and Pseudomonas aeruginosa, are ...

2004年5月1日 · Type IV pili are remarkably strong, flexible filaments with varied roles in bacterial pathogenicity. All Gram-negative bacterial surfaces have type IV pili, which are polymeric assemblies of...

2015年2月27日 · In this study we described the high-resolution structure of the N-terminally truncated type IV pilin Pil Bac1 which exhibits the typical fold of type IV pilins with a long N-terminal α-helix packed against 4 antiparallel β-strands.

2020年5月6日 · Here, we use cryo-electron microscopy and mass spectrometry to show that the bacterium Thermus thermophilus produces two forms of type IV pilus (‘wide’ and ‘narrow’), differing in structure and...

2020年5月1日 · Cell-surface-located proteinaceous appendages, such as flagella and fimbriae or pili, are ubiquitous in bacterial communities. Here, we focus on conserved type IV pili (T4P) produced by bacteria in the intestinal tract, one of the …

Type IV pili (T4P) are surface-exposed fibers that mediate many functions in bacteria, including locomotion, adherence to host cells, DNA uptake (competence), and protein secretion and that can act as nanowires carrying electric current.

2024年11月28日 · Type IV pili are hair-like appendages on many bacteria, playing a role in bacterial physiology and pathogenicity. These structures are involved in functions such as motility, biofilm formation, and host interaction, making them a focus of study in microbiology.