2015年2月26日 · Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct cytogenetic subgroup of childhood B-cell precursor acute lymphoblastic leukemia. Breakage-fusion-bridge cycles followed by chromothripsis and other complex structural rearrangements of chromosome 21 underlie the mechanism giving rise to iAMP21.

iAMP21是一种复杂的遗传学异常，在患者中具有高度异质性，该异常的形成可能与断裂融合桥 (BFB)循环、rob (15；21)c和r (21)c相关。 iAMP21－ALL与发病年龄大、较低的白细胞和血小板计数及不良预后相关，增加化疗强度可改善患儿的预后。 现就iAMP21－ALL的遗传学异常、形成机制、临床特点及预后和治疗方面的研究进展进行综述。 引用本文: 杨文慧, 曾慧敏. 伴21号染色体内部扩增的急性淋巴细胞白血病研究进展 [J] . 中华实用儿科临床杂志, 2020, 35 (15) : 1191 …

2023年8月24日 · Overall, this study elegantly integrates WGS and WTS data to provide a detailed characterization of iAMP21-ALL, defining the key region of amplification and the set of differentially expressed genes; highlighting the importance of copy number profiling to identify variant cases; and suggesting the timing of acquisition of somatic alterations.

2020年2月7日 · Intrachromosomal amplification of chromosome 21 (iAMP21) is an uncommon finding in hematologic neoplasms that is most often detected by fluorescence in situ hybridization...

2023年8月24日 · Intrachromosomal amplification of chromosome 21 defines a subtype of high-risk childhood acute lymphoblastic leukemia (iAMP21-ALL) characterized by copy number changes and complex rearrangements of chromosome 21.

第21号染色体内部扩增（iAMP21）是一组独特的急性B淋巴细胞白血病（B-ALL）细胞遗传学亚群。 既往使用标危方案治疗伴iAMP21 B-ALL患者时，复发率很高，而强化疗有助于改善预后 [1, 2]。 目前国内对伴iAMP21急性淋巴细胞白血病（ALL）少有报道。

2013年10月29日 · Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct cytogenetic subgroup of childhood B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). To...

2022年7月19日 · Acute lymphoblastic leukemia (B‐ALL) with intrachromosomal amplification of chromosome 21 (iAMP21‐ALL) represents a recurrent high‐risk cytogenetic abnormality and accurate identification is critical for appropriate clinical management.

Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct cytogenetic subgroup of childhood B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). To date, fluorescence in situ hybridisation (FISH), with probes specific for the RUNX1 gene, provides the only reliable detection me …

2015年2月26日 · Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct cytogenetic subgroup of childhood B-cell precursor acute lymphoblastic leukemia. Breakage-fusion-bridge cycles followed by chromothripsis and other complex structural rearrangements of chromosome 21 underlie the mechanism gi …